Journal ArticleDOI
Direct evidence for an axonal site of action of capsaicin.
Jancśo G,Király E,Jancsó-Gábor A +2 more
TLDR
It is suggested that local capsaicin treatment of peripheral nerves selectively damages the chemosensitive nerve fibres presumably by depleting their substance P content.Abstract:
1.
Local application of capsaicin to the sciatic nerve of rats induced a long-lasting increase in the nociceptive threshold as tested by the hot-plate method, and prevented neurogenic inflammation in the lateral part of the dorsal skin of the rat's paw.
2.
Application of capsaicin to the saphenous nerve prevented the neurogenic inflammatory response, induced either by antidromic electrical stimulation of the saphenous nerve or by painting the skin with mustard oil, in the medial part of the dorsal skin of the paw.
3.
The functional impairment induced by local capsaicin treatment of saphenous or sciatic nerves was strictly confined to the skin area supplied by the corresponding nerve.
4.
It is suggested that local capsaicin treatment of peripheral nerves selectively damages the chemosensitive nerve fibres presumably by depleting their substance P content.read more
Citations
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Journal ArticleDOI
The sensory-efferent function of capsaicin-sensitive sensory neurons
Carlo Alberto Maggi,Alberto Meli +1 more
TL;DR: Development of drugs capable of controlling the sensory-efferent functions of the capsaicin-sensitive sensory neurons represent a new and very promising area of research for pharmacological treatment of various human diseases.
Journal ArticleDOI
Asthma as an axon reflex
TL;DR: In asthma, damage to airway epithelium, possibly caused by eosinophil products, exposes C-fibre afferent nerve endings and Stimulation of these endings by inflammatory mediators may result in an axon (local) reflex, which could account for at least some of the pathophysiology of asthma and this concept might lead to new strategies for treatment.
Journal ArticleDOI
Capsaicin and sensory neurones--a review.
TL;DR: This review was written as a result of a meeting on capsaicin in November 1981 at the Medical Research Council in London, where neuroscientists of different disciplines who had used capsicin in their research or studied its mode of action came together to discuss problems.
Journal ArticleDOI
Sympathetic and sensory innervation of brown adipose tissue
TL;DR: The recent recognition of BAT in normal adult humans suggests a potential target for stimulation of energy expenditure by BAT to help mitigate increased body fat storage.
Journal ArticleDOI
Immunohistochemical studies on the effect of capsaicin on spinal and medullary peptide and monoamine neurons using antisera to substance P, gastrin/CCK, somatostatin, VIP, enkephalin, neurotensin and 5-hydroxytryptamine.
Gábor Jancsó,Tomas Hökfelt,Jan M. Lundberg,E. Kiraly,N. Halász,Göran E. Nilsson,Göran E. Nilsson,Lars Terenius,Lars Terenius,Jens F. Rehfeld,Harry Steinbusch,A. Verhofstad,Robert Elde,S. Said,M. Brown +14 more
TL;DR: The results demonstrate that the effects of Capsaicin are not confined to substance P immunoreactive primary sensory neurons, and the possibility is discussed that capsaicin effects specifically functioning rather than chemically specific primary sensory cells.
References
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Journal ArticleDOI
Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones
TL;DR: It is reported here that selective degeneration of neurones with a highly specific function can be produced by chemical agents in the somatosensory system as well.
Journal ArticleDOI
Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation
Fred Lembeck,Peter Holzer +1 more
TL;DR: It is concluded that vasodilation and plasma extravasation following antidromic stimulation of sensory nerves are initiated by peripheral release of substance P from chemosensitive pain fibres.
Journal ArticleDOI
Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin
Journal ArticleDOI
Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons.
TL;DR: The present results give strong evidence for the occurrence of SP in a certain population of primary sensory neurons and support earlier findings that SP may act as a transmitter or modulator in these neurons.
Journal ArticleDOI
Capsaicin-induced depletion of substance P from primary sensory neurones.
TL;DR: Observations strongly support the concept that substance P acts as a primary sensory transmitter and the administration of capsaicin, which is known to desensitize peripheral receptors responding to painful chemogenic stimuli, virtually abolishes the fluoride-resistant acid phosphatase activity of the substantia gelatinosa.