Journal ArticleDOI
Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones
TLDR
It is reported here that selective degeneration of neurones with a highly specific function can be produced by chemical agents in the somatosensory system as well.Abstract:
PHARMACOLOGICALLY evoked selective degeneration of neurones with a specific function or functioning with known transmitter substances, has been reported only in the monoaminergic neurone systems1,2. We report here that selective degeneration of neurones with a highly specific function can be produced by chemical agents in the somatosensory system as well. Capsaicin given to newborn rats induces selective degeneration of a distinct population of primary sensory neurones involved in mediation of chemogenic pain.read more
Citations
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The capsaicin receptor: a heat-activated ion channel in the pain pathway
Michael J. Caterina,Mark Schumacher,Makoto Tominaga,Tobias A. Rosen,Jon D. Levine,David Julius +5 more
TL;DR: The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
Journal ArticleDOI
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
Makoto Tominaga,Michael J. Caterina,Annika B. Malmberg,Tobias A. Rosen,Heather Gilbert,Kate Skinner,Brigitte E Raumann,Allan I. Basbaum,David Julius +8 more
TL;DR: It is shown that protons decrease the temperature threshold for VR1 activation such that even moderately acidic conditions (pH < or = 5.9) activate VR1 at room temperature, and VR1 can be viewed as a molecular integrator of chemical and physical stimuli that elicit pain.
Journal ArticleDOI
Calcitonin gene-related peptide is a potent vasodilator
TL;DR: It is suggested that local extravascular release of CGRP may be involved in the physiological control of blood flow and that circulating C GRP may contribute to hyperaemia in certain pathological conditions.
Journal Article
Vanilloid (Capsaicin) Receptors and Mechanisms
Arpad Szallasi,Peter M. Blumberg +1 more
TL;DR: This paper focuses on hot pepper, which is eaten on a daily basis by an estimated one-quarter of the world’s population and has potential to be a biological target for regenerative medicine.
Journal ArticleDOI
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Sven-Eric Jordt,Diana M. Bautista,Huai-hu Chuang,David D. McKemy,Peter M. Zygmunt,Edward D. Högestätt,Ian D. Meng,Ian D. Meng,David Julius +8 more
TL;DR: It is shown that mustard oil depolarizes a subpopulation of primary sensory neurons that are also activated by capsaicin, the pungent ingredient in chilli peppers, and by Δ9-tetrahydrocannabinol, the psychoactive component of marijuana.
References
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Journal ArticleDOI
Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat.
Tomas Hökfelt,Tomas Hökfelt,Robert Elde,Robert Elde,O. Johansson,O. Johansson,R. Luft,R. Luft,G. Nilsson,G. Nilsson,Akira Arimura,Akira Arimura +11 more
TL;DR: The present results indicate that two subpopulations of primary sensory neurons exist, one containing somatostatin, or som atostatin-like immunoreactivity, and the other containing substance P, or substance P-like Immunoreactivity.
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[Research on the fine-structure of spinal ganglia].
TL;DR: Mit einander erganzenden phasenkontrast- und elektronenmikroskopischen Untersuchungen an Ultradunnschnitten osmiumtetroxydfixierter Rattenspinalganglien wurde ein relativ umfangreiches Material ausgewertet as discussed by the authors.
Journal ArticleDOI
Mitochondrial alterations in the spinal ganglion cells of the rat accompanying the long-lasting sensory disturbance induced by capsaicin.
Journal ArticleDOI
A reliable staining method for semi-thin sections in experimental neuroanatomy
TL;DR: The technique for the staining of degenerating nerve fibres of all sizes in Araldite semi-thin sections is described, very valuable for the accurate selection and trimming of blocks with fibre degeneration used for electron microscopy.