Journal ArticleDOI
Direct Inhibition by Ergocornine of Pituitary Prolactin Release
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TLDR
When given together, ERG partially counteracted EB stimulation of pituitary and serum prolactin levels and mammary growth, whereas EB increased both AP and serum Prolactin concentrations and Mammary growth.Abstract:
The effects of ergocornine, estradiol benzoate (EB) or both on anterior pituitary (AP) and serum prolactin concentrations were studied in ovariectomized or hypophysectomized rats with a pituitary transplant, and directly on the AP in vitro. Injections of 5 or 10 μg EB into ovariectomized rats for 5 days produced 3-to 4-fold increase in AP prolactin concentration, a 6-to 8-fold rise in serum prolactin and increases in pituitary weight and mammary growth. Doses of 0.1 or 0.3 mg ergocornine methanesulfonate (ERG) partially or completely inhibited the stimulatory effects of EB on each of these parameters. Transplantation of one AP into the kidney capsule of hypophysectomizedovariectomized rats resulted in relatively high blood prolactin levels. ERG reduced prolactin release from the AP graft and mammary growth, whereas EB increased both AP and serum prolactin concentrations and mammary growth. When given together, ERG partially counteracted EB stimulation of pituitary and serum prolactin levels and mammary gr...read more
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Journal ArticleDOI
Medial preoptic area and onset of maternal behavior in the rat.
TL;DR: It was concluded that the medial preoptic area (MPOA) is involved not only in the maintenance of maternal behavior but in the hormonally mediated onset of mothers behavior and the onset of maternalbehavior induced in virgin females by pup stimulation.
Book ChapterDOI
Hypothalamic control of prolactin secretion.
TL;DR: This chapter emphasizes the current concepts and observations hypothalamic control of prolactin secretion, and suggests a useful approach for controlling the secretion and functions of Prolactin in the organism.
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Damage to hypothalamic dopaminergic neurons is associated with development of prolactin-secreting pituitary tumors
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Effects of Estradiol and Progesterone on Plasma Gonadotropins, Prolactin, and LHRH in Specific Brain Areas of Ovariectomized Rats
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Suppression of Pituitary Tumor Growth and Function by Ergot Alkaloids
TL;DR: The in vivo and in vitro effects of ergot derivatives on prolactin and growth hormone biosynthesis in the rat have been studied and ergotamine alone was able to overcome the atrophy of the pituitary glands of tumor-bearing animals and allow gland function to return toward normal.