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Discriminating behavior of metal ions and ligands with regard to their biological significance
Helmut Sigel,Donald B. McCormick +1 more
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This article is published in Accounts of Chemical Research.The article was published on 1970-06-01. It has received 260 citations till now.read more
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Structural and Functional Aspects of Metal Sites in Biology
TL;DR: The authors present here a classification and structure/function analysis of native metal sites based on these functions, and the coordination chemistry of metalloprotein sites and the unique properties of a protein as a ligand are briefly summarized.
Journal ArticleDOI
Application of metal coordination chemistry to explore and manipulate cell biology.
TL;DR: Inorganic compounds should not be overlooked in the realm of chemical biology, since their distinctive electronic, chemical, and photophysical properties render them particularly useful for a variety of applications.
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Coordination geometries of selected transition metal ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, and Hg2+) in metalloproteins.
Lubomír Rulíšek,Jiří Vondrášek +1 more
TL;DR: The correlation between the geometries of small-molecule crystal structures and the metal-binding sites in metalloproteins was investigated and it follows that the octahedral arrangement is preferred by Co2+ and Ni2+, tetrahedral by Zn2+, square planar by Cu2+.
Journal ArticleDOI
Ternary Cu2+ Complexes: Stability, Structure, and Reactivity
TL;DR: In this article, the driving forces leading to the formation of ternary Cu2+ complexes are outlined; they are (i) statistical reasons, neutralization of charge in the mixed-ligand complexes, steric factors (bulky groups, ring size of chelates), and formation of π bonds.
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Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry.
TL;DR: A molecular model building computer program (DEZYMER) is devised which builds new ligand binding sites into a protein of known three-dimensional structure, altering only the sequence and the side-chain structure, leaving the protein backbone fold intact by definition.
References
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Journal ArticleDOI
Hard and soft acids and bases, HSAB, part 1: Fundamental principles
TL;DR: Using the principles of hard and soft acids and bases to estimate the strength and softness of an acid or base was proposed in this article, where the soft acid base was considered.
Journal ArticleDOI
637. The stability of transition-metal complexes
H. Irving,R. J. P. Williams +1 more
Journal ArticleDOI
Order of Stability of Metal Complexes
H. Irving,R. J. P. Williams +1 more
TL;DR: In this article, the stability of complexes of bivalent metal ions follows the order of the order in which they are formed, and it is shown that the stability is not correlated with the order.
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Interaction of metal ions with polynucleotides and related compounds. XII. The relative effect of various metal ions on DNA helicity
Journal ArticleDOI
Metalloenzymes: the entatic nature of their active sites
Bert L. Vallee,R. J. P. Williams +1 more
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Ternary complexes in solution. VIII. Complex formation between the copper(II)-2,2'-bipyridyl 1:1 complex and ligands containing oxygen and/or nitrogen donor atoms
Rolf Griesser,Helmut Sigel +1 more