Journal ArticleDOI
Divalproex in the treatment of alcohol withdrawal.
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TLDR
This preliminary study supports further investigation of divalproex in the treatment of alcohol withdrawal and supports the use of lorazepam in patients with uncomplicated alcohol withdrawal syndrome.Abstract:
The present study represents an open-label clinical trial comparing treatment with a benzodiazepine (lorazepam) to divalproex in 11 inpatients with uncomplicated alcohol withdrawal syndrome. The tr...read more
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Reference EntryDOI
Benzodiazepines for alcohol withdrawal
TL;DR: Benzodiazepines are effective against alcohol withdrawal symptoms, in particular seizures, when compared to placebo, and it is not possible to draw definite conclusions about the relative effectiveness and safety of benzodiazepine against other drugs in alcohol withdrawal, because of the large heterogeneity.
Journal ArticleDOI
Benzodiazepines for alcohol withdrawal
TL;DR: Benzodiazepines showed a protective benefit against alcohol withdrawal symptoms, in particular seizures, when compared to placebo and a potentially protective benefit for many outcomes when compared with other drugs.
Journal ArticleDOI
Bipolar disorder and comorbid alcoholism: prevalence rate and treatment considerations.
Mark A. Frye,Ihsan M. Salloum +1 more
TL;DR: Clinical studies that have evaluated the effectiveness of conventional mood stabilizers (lithium, carbamazepine, divalproex, and atypical antipsychotics) in the treatment of alcohol withdrawal and relapse prevention in patients with alcoholism and in thetreatment of bipolar disorder with comorbid alcoholism are reviewed.
Journal ArticleDOI
A review of valproate in psychiatric practice.
TL;DR: Preliminary evidence has linked in utero exposure to decreased verbal intelligence in the offspring, limit valproate's use in women of childbearing potential, and maintenance treatment with Valproate and quetiapine or olanzapine is more efficacious thanValproate alone when an acute episode responds to the combination.
Journal ArticleDOI
The use of divalproex in alcohol relapse prevention: a pilot study.
TL;DR: While DVPX did not have a robust effect on alcohol-related outcomes, it did have modest impact on a measure of irritability, consistent with the findings of other investigators exploring the use of DVPx in schizophrenia, personality disorder and a number of other psychiatric disorders.
References
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Journal ArticleDOI
Efficacy of Divalproex vs Lithium and Placebo in the Treatment of Mania
Charles L. Bowden,Andrew M. Brugger,Alan C. Swann,Joseph R. Calabrese,Philip G. Janicak,Frederick Petty,Steven C. Dilsaver,John M. Davis,A. John Rush,Joyce G. Small,Enrique S. Garza-Treviño,S.Craig Risch,Paul J. Goodnick,David D. Morris,V.S. Shu,Philip C. Johnson,M. Blake,Martin A Javors,Larry Ereshefsky,Terry McLeod,Arif M. Shoaib,Mark H. Johnson,Susan E. Kimmel,A. Wesley,R. Qualtiere,C. Trivedi,J. I. Javaid,Jeremy C. Peterson,Michael T. Lambert,Martin D. Zielinski,Paul J. Orsulak,L. Sharp,L. Akers,Marvin J. Miller,Jeffrey J. Kellams,G. Woodham,Alan Frazer +36 more
TL;DR: Divalproex was as effective in rapid-cycling manic patients as in other patients and appears to be independent of prior responsiveness to lithium, while lithium was significantly more effective than placebo in reducing the symptoms of acute mania.
Journal ArticleDOI
Double-blind controlled trial comparing carbamazepine to oxazepam treatment of alcohol withdrawal.
TL;DR: It is suggested that carbamazepine is as effective and safe as benzodiazepine treatment for alcohol withdrawal and not significantly different with respect to side effects.
Journal ArticleDOI
Carbamazepine treatment in patients discontinuing long-term benzodiazepine therapy. Effects on withdrawal severity and outcome.
TL;DR: The results of this pilot investigation suggest that carbamazepine might have promise as an adjunctive drug therapy for the benzodiazepine withdrawal syndrome, particularly in patients receiving Benzodiazepines in daily dosages of 20 mg/d or greater of diazepam equivalents.
Journal ArticleDOI
An update on sodium valproate.
Elizabeth M. Rimmer,Alan Richens +1 more
TL;DR: Most adverse reactions to sodium valproate are mild and reversible, but with increasing experience, the drug's rare, idiosyncratic, adverse effects are becoming apparent, particularly hepatotoxicity and teratogenicity.
Journal ArticleDOI
Sodium valproate and cognitive function.
TL;DR: It was concluded that sodium valproate has minimal adverse effects, although those that are seen are probably dose related.