Journal ArticleDOI
Divergent effects of epinephrine and prostaglandin E1 on the level of cyclic AMP in human blood platelets
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The study results add to the evidence that the level of cyclic AMP in blood platelets is an important determinant of the aggregation tendency of these cells.About:
This article is published in Pharmacological Research Communications.The article was published on 1969-09-01. It has received 118 citations till now. The article focuses on the topics: Phentolamine & Platelet.read more
Citations
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Modulation of human platelet adenylate cyclase by prostacyclin (PGX).
TL;DR: A model of platelet homeostasis is proposed that suggests platelet aggregation is controlled by a balance between the adenylate cyclase stimulating activity of prostacyclin, and the cAMP lowering activity of PGH2.
Journal ArticleDOI
Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets
TL;DR: Prostacyclin (PGX) strikingly increases cyclic AMP concentrations in human platelets, and these results correlate well with the anti-aggregating activity of prostacyClin, compared with PGE1 and PGD2.
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Studies on the role of adenosine 3',5'-monophosphate in the hepatic actions of glucagon and catecholamines.
TL;DR: The hypothesis is discussed in terms of the hypothesis that glucagon and catecholamines act in the liver by increasing the concentration of free, metabolically active cyclic AMP, and that this represents only a small fraction of the total tissue cyclicAMP.
References
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Journal ArticleDOI
Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.
R.W. Butcher,Earl W. Sutherland +1 more
TL;DR: Data indicated a significant role for the enzyme in the control of the levels of adenosine 3’,5’-phosphate present in biological systems, which was very desirable because of the extremely low levels present in most biological materials.
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Morphology and enumeration of human blood platelets.
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Adenyl cyclase as an adrenergic receptor
TL;DR: Little is known, in chemical terms, about the reasons for the hormonal specificity in different tissues, and the particulate nature of adenyl cyclase in most tissues, together with its lability have combined to make the purification and study of this enzyme difficult.
Journal Article
The prostaglandins: a family of biologically active lipids
TL;DR: The prostaglandins are a family of lipids, originally discovered over 30 years ago in human seminal fluid, which have since been found not only to have a wide variety of striking pharmacological actions, but also to be present in many if not all mammalian tissues.
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