Journal ArticleDOI
Double jeopardy: schizophrenia and substance use.
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TLDR
The findings further emphasize the impact of substance use on outcome in schizophrenia and the need for more research on the nature and treatment of the patient with a dual diagnosis.Abstract:
Objective: Although the clinical reality of substance dependence and/or abuse among schizophrenia patients is widely acknowledged, the interaction of these diagnoses is not well understood. Perhaps the largest study documenting the comorbidity of substance abuse is the Epidemiologic Catchment Area (ECA) study, which found the rate to be 47% in schizophrenia patients . The present study examined substance use and compared the broad categories of substance users versus nonusers vis-a-vis schizophrenic symptomatology, hospitalizations, compliance, and demographic variables. We further examined the two subcategories of alcohol versus other substances of abuse (hereafter called “drugs”) to determine differences. Methods: Data were collected by the same person retrospectively from the charts of schizophrenia outpatients in a public inner city mental health center. Patients must have had at least 10 outpatient visits within a 2-year period for data to be used. Results: Data were compiled from 262 charts. Of the ...read more
Citations
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Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for Psychopharmacology:
TL;DR: These guidelines from the British Association for Psychopharmacology address the scope and targets of pharmacological treatment for schizophrenia, and cover the pharmacological management and treatment of schizophrenia across the various stages of the illness.
Journal ArticleDOI
Postmortem assessment of thalamic nuclear volumes in subjects with schizophrenia.
William Byne,Monte S. Buchsbaum,Linda A. Mattiace,Erin A. Hazlett,Eileen Kemether,Sharif L. Elhakem,Dushyant P. Purohit,Vahram Haroutunian,Liesl B. Jones +8 more
TL;DR: Schizophrenia is associated with volume and neuronal changes in the mediodorsal nucleus and pulvinar, the major association nuclei of the thalamus, whereas total thalamic volume and the volumes of anterior and centromedian nuclei were not significantly altered.
Journal ArticleDOI
Substance Use Disorders in Schizophrenia—Clinical Implications of Comorbidity
TL;DR: It is critically important to address this comorbidity because SUD in schizophrenic patients is associated with poorer clinical outcomes and contributes significantly to their morbidity and mortality.
Journal ArticleDOI
Prevalence of comorbid substance use in schizophrenia spectrum disorders in community and clinical settings, 1990-2017: Systematic review and meta-analysis.
TL;DR: SUDs in schizophrenia is highly prevalent and rates have not changed over time, which indicates SUD are difficult to treat in this patient population and there is an urgent need for more informative studies to help develop better prevention, detection and treatment of Suds in persons with schizophrenia and co-morbid disorders.
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Women with schizophrenia: pregnancy outcome and infant death among their offspring.
Emma Nilsson,Paul Lichtenstein,Sven Cnattingius,Robin M. Murray,Christina M. Hultman,Christina M. Hultman +5 more
TL;DR: It is concluded that schizophrenia in the mother implies an increased risk for poor perinatal outcome, not fully explained by maternal factors, and a need to consider a common familial (probably genetic) vulnerability for pre- and per inatal stress and schizophrenia.
References
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[Affective disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association -- diagnostic and statistical manual of mental disorders].
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The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
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Comorbidity of Mental Disorders With Alcohol and Other Drug Abuse. Results From the Epidemiologic Catchment Area (ECA) Study
Darrel A. Regier,Mary E. Farmer,Donald S. Rae,Ben Z. Locke,Samuel J. Keith,Lewis L. Judd,Frederick K. Goodwin +6 more
TL;DR: Comorbidity of addictive and severe mental disorders was highest in the prison population, most notably with antisocial personality, schizophrenia, and bipolar disorders.
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Molecular pathology of schizophrenia: more than one disease process?
TL;DR: In Florence showed some symptomatic improvement with only minor side effects, but this requires confirmation in a controlled trial, and another approach is based on the finding that suppressor lymphocyte activity is depressed during acute relapses in multiple sclerosis.