Journal ArticleDOI
Dyslipidaemia in overweight children and adolescents is associated with an increased risk of kidney stones.
Jan K. Kirejczyk,Agata Korzeniecka-Kozerska,M Baran,Halina Porowska,Tadeusz Porowski,Anna Wasilewska +5 more
TLDR
This Polish study explored the influence of nutritional status and lipid disturbances on urinary lithogenic factors and the risk of kidney stone formation in children and adolescents from three to 18 years of age.Abstract:
Aim
There is conflicting evidence about the role of obesity in paediatric nephrolithiasis. This Polish study explored the influence of nutritional status and lipid disturbances on urinary lithogenic factors and the risk of kidney stone formation in children and adolescents from three to 18 years of age.
Methods
We carried out serum lipid profile evaluations and 24-h urine chemistry analyses on 493 overweight/obese paediatric participants (mean age 13 years) without nephrolithiasis and 492 healthy normal weight sex and age-matched controls.
Results
A third (33%) of the study group had blood lipid disturbances, with more acidic urine, lower urinary citrate excretion and a higher fraction of ionised calcium and higher Bonn Risk Index than the controls. The participants' body mass index standard deviation score (BMI Z-score) was positively correlated with urinary oxalate and uric acid and negatively correlated with citrate excretion. Total cholesterol, low-density lipoprotein cholesterol and triglycerides correlated negatively with citraturia, while high-density lipoprotein cholesterol correlated positively.
Conclusion
The main factor that predisposed overweight and obese children to kidney stones was hypocitraturia. Urinary citrate excretion was related to both BMI Z-scores and all lipid fraction abnormalities. However, hypercholesterolaemia and particularly low-density lipoprotein hypercholesterolaemia seemed to play a major role.read more
Citations
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Journal ArticleDOI
Elevated non-high-density lipoprotein cholesterol corresponds to a high risk of nephrolithiasis in children
TL;DR: Non-high-density lipoprotein cholesterol may act as a lipid risk factor for urolithiasis in children and be associated with percentage of uric acid and pure calcium oxalate stones.
Journal ArticleDOI
Alteraciones urinarias en niños litiásicos paraguayos según estado nutricional
TL;DR: In this article, the frecuencia de alteraciones urinarias presentes in ninos with urolitiasis segun estado nutricional was investigated.
Journal ArticleDOI
Metabolic syndrome and stone disease
TL;DR: In this article , a review of the available evidence regarding the association between metabolic syndrome and nephrolithiasis, the biological mechanisms linking metabolic disease and its trait to kidney formation, and stone composition in individuals affected by metabolic syndrome is presented.
Journal ArticleDOI
Metabolic syndrome traits in urolithiasis patients
Johannes Aritonang,Zulfikar Ali +1 more
TL;DR: Not all of the MetS traits found in patients diagnosed with urolithiasis in Kardinah Hospital from April to June 2018, who were screened for metabolic syndrome criteria are found, and this observational study needs further research to confirm the correlation between urology and MetS.
Journal ArticleDOI
Hydroxycitric acid inhibits kidney stone through crystallization regulation and reduction of hyperoxalate-induced lipotoxicity
TL;DR: In this paper , the authors explored the molecular mechanisms of Hydroxycitric acid (HCA) inhibition of renal calcium oxalate (CaOx) deposition and nephrotoxicity.
References
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Journal ArticleDOI
High body mass index for age among US children and adolescents, 2003-2006.
TL;DR: The prevalence of high BMI for age among children and adolescents showed no significant changes between 2003-2004 and 2005-2006 and no significant trends between 1999 and 2006.
Journal ArticleDOI
Obesity, Weight Gain, and the Risk of Kidney Stones
TL;DR: Obesity and weight gain increase the risk of kidney stone formation, and the magnitude of the increased risk may be greater in women than in men.
Journal ArticleDOI
The metabolic syndrome in children and adolescents
Paul Zimmet,George Alberti,George Alberti,Francine R. Kaufman,Naoko Tajima,Martin Silink,Silva A. Arslanian,Gary Wong,Peter H. Bennett,Jonathan E. Shaw,Sonia Caprio +10 more
TL;DR: As the programme grows, these actions will pose new problems for the sus tainability of large-scale CHW programmes, and might again lay bare the tensions between the diff erent expec tations and descriptions of the CHW.
Journal ArticleDOI
Metabolic syndrome in children and adolescents.
Dania Al-Hamad,Vandana Raman +1 more
TL;DR: Prevalence of metabolic syndrome in children and adolescents is increasing, in parallel with the increasing trends in obesity rates, and variations in definitions of this syndrome have hindered the development of a consensus for the diagnostic criteria in the pediatric population.
Journal ArticleDOI
Body Size and 24-Hour Urine Composition
Eric N. Taylor,Gary C. Curhan +1 more
TL;DR: Positive associations between BMI and urinary calcium excretion likely are due to differences in animal protein and sodium intake and may be due to an increase in uric acid nephrolithiasis.