Journal ArticleDOI
Dyslipidaemia in overweight children and adolescents is associated with an increased risk of kidney stones.
Jan K. Kirejczyk,Agata Korzeniecka-Kozerska,M Baran,Halina Porowska,Tadeusz Porowski,Anna Wasilewska +5 more
TLDR
This Polish study explored the influence of nutritional status and lipid disturbances on urinary lithogenic factors and the risk of kidney stone formation in children and adolescents from three to 18 years of age.Abstract:
Aim
There is conflicting evidence about the role of obesity in paediatric nephrolithiasis. This Polish study explored the influence of nutritional status and lipid disturbances on urinary lithogenic factors and the risk of kidney stone formation in children and adolescents from three to 18 years of age.
Methods
We carried out serum lipid profile evaluations and 24-h urine chemistry analyses on 493 overweight/obese paediatric participants (mean age 13 years) without nephrolithiasis and 492 healthy normal weight sex and age-matched controls.
Results
A third (33%) of the study group had blood lipid disturbances, with more acidic urine, lower urinary citrate excretion and a higher fraction of ionised calcium and higher Bonn Risk Index than the controls. The participants' body mass index standard deviation score (BMI Z-score) was positively correlated with urinary oxalate and uric acid and negatively correlated with citrate excretion. Total cholesterol, low-density lipoprotein cholesterol and triglycerides correlated negatively with citraturia, while high-density lipoprotein cholesterol correlated positively.
Conclusion
The main factor that predisposed overweight and obese children to kidney stones was hypocitraturia. Urinary citrate excretion was related to both BMI Z-scores and all lipid fraction abnormalities. However, hypercholesterolaemia and particularly low-density lipoprotein hypercholesterolaemia seemed to play a major role.read more
Citations
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Journal ArticleDOI
Untargeted lipidomics based on UPLC-QTOF-MS/MS and structural characterization reveals dramatic compositional changes in serum and renal lipids in mice with glyoxylate-induced nephrolithiasis.
TL;DR: A mouse model for renal urolithiasis is established and it is found that polyunsaturated fatty acids mediated inflammatory responses and that the oxidative stress induced by oleylethanolamine and glycerophosphoethanolamine plasmalogens is closely related to the development of kidney stones.
Journal ArticleDOI
Pediatric Nephrolithiasis: Trend, Evaluation and Management: A Systematic Review
TL;DR: Evaluation of patients, particularly young children, includes metabolic assessment, andStone analysis and 24-urine collection analysis are very helpful for determining underlying diseases, and pediatric nephrolithiasis has an increasing rate worldwide.
Journal ArticleDOI
Idiopathic Osteoporosis and Nephrolithiasis: Two Sides of the Same Coin?
Domenico Rendina,Gianpaolo De Filippo,Gabriella Iannuzzo,V. Abate,Pasquale Strazzullo,Alberto Falchetti +5 more
TL;DR: It is proposed to consider idiopathic nephrolithiasis and osteoporosis as two possible expressions of a unique clinical syndrome and the clinical approach to both disorders should be modified in order to program an efficient primary and secondary prevention strategy.
Journal ArticleDOI
Kidney Stones as an Underrecognized Clinical Sign in Pediatric Cushing Disease
Sara H. Rahman,Georgios Z. Papadakis,Margaret F. Keil,Fabio R. Faucz,Maya Lodish,Constantine A. Stratakis +5 more
TL;DR: It is illustrated that kidney stones are an underestimated complication of pediatric CD, especially when compared with the prevalence of nephrolithiasis in the general pediatric population.
Journal ArticleDOI
Lipidomics Reveals the Therapeutic Effects of EtOAc Extract of Orthosiphon stamineus Benth. on Nephrolithiasis.
TL;DR: The EEOS can inhibit the stones formation by improving oxidative stress and inflammation mediated by glycerophospholipid metabolism, providing a new direction for further study of the efficacy of OS.
References
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Journal ArticleDOI
Hypertriglyceridemia and Low High-Density Lipoprotein Cholesterolemia Are Associated with Increased Hazard for Urolithiasis
Ho Won Kang,Sang Keun Lee,Won-Tae Kim,Yong-June Kim,Seok Joong Yun,Sang-Cheol Lee,Wun-Jae Kim +6 more
TL;DR: Compared with controls, the SF group had significantly higher mean triglyceride and lower total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density cholesterol levels (each P<0.001).
Journal ArticleDOI
Metabolic syndrome in obese adolescents is associated with risk for nephrolithiasis.
Rishita Tiwari,Thomas Campfield,Chrystal Wittcopp,Gregory Braden,Paul Visintainer,Edward O. Reiter,Holley Allen +6 more
TL;DR: Low urinary pH and increased RSR-CaOx are associated with risk factors for metabolic syndrome in obese adolescents, and both homeostasis model assessment of insulin resistance score and number of risk factorsfor metabolic syndrome were negatively correlated.
Journal ArticleDOI
Correspondence between Ca2+ and calciuria, citrate level and pH of urine in pediatric urolithiasis
Tadeusz Porowski,Jan K. Kirejczyk,Jerzy Konstantynowicz,Anna Kazberuk,Grzegorz Plonski,Anna Wasilewska,Norbert Laube +6 more
TL;DR: Compared to controls, stone-formers with hypocitraturia demonstrated a higher urinary Ca2+ concentration, but this was proportional to calciuria, and the Ca/Citrate ratio may be a useful clinical tool in evaluating children with urolithiasis.
Journal ArticleDOI
Metabolic Evaluation of Urolithiasis and Obesity in a Midwestern Pediatric Population
TL;DR: This study supports the majority of published series that have failed to establish a link between pediatric urolithiasis and obesity and found no substantial metabolic differences between healthy nonobese stone formers and obese patients.
Journal ArticleDOI
Bonn Risk Index Based Micromethod for Assessing Risk of Urinary Calcium Oxalate Stone Formation
Tadeusz Porowski,Piotr Mrozek,J. Sidun,Walentyna Zoch-Zwierz,Jerzy Konstantynowicz,Jan K. Kirejczyk,Radosław Motkowski,Norbert Laube +7 more
TL;DR: Assessment of risk of urinary calcium oxalate stone formation with Bonn Risk Index in small urine volumes, based on prototype equipment controlled by specialized computer software, is comparable to the original method.