Journal ArticleDOI
Effect of a new De-N-acetyl-lysoglycosphingolipid on chemically-induced inflammatory bowel disease: possible mechanism of action
TLDR
A new, orally active de-N-acetylated lysoglycosphingolipid (WILD20) was evaluated as antiinflammatory agent using a model of chemically-induced inflammatory bowel disease (IBD) in the rat to mimic human ulcerative colitis and Chron's disease.Abstract:
A new, orally active de-N-acetylated lysoglycosphingolipid (WILD20) was evaluated as antiinflammatory agent using a model of chemically-induced inflammatory bowel disease (IBD) in the rat to mimic human ulcerative colitis and Chron's disease. IBD was induced by hapten trinitrobenzenesulphonic acid (TNB). WILD20, orally administered as preventive or curative, was demonstrated to be efficacious at daily dosages of 0.1–1 mg/kg for 4–5 days. Damage scores, body weight, spleen weight, colonic tissular levels of LTB4, myeloperoxidase (MPO) and malondialdehyde (MDA) are influenced and brought into parameters of normality.read more
Citations
More filters
Journal ArticleDOI
Phospholipase A2 inhibitors in development.
U Tibes,W G Friebe +1 more
TL;DR: Indications for which PLA2 inhibitors are being pursued include, sepsis, acute pancreatitis, inflammatory skin and bowel diseases, asthma, and rheumatoid arthritis, and there are no likely clinical candidates emerging from the ranks of cPLA2 and iPLA2 inhibitors in development.
Journal ArticleDOI
The effect of Oren-gedoku-to on experimental colitis in rats.
Haiyan Zhou,Satoru Mineshita +1 more
TL;DR: The effect of Oren‐gedoku‐to with salicylazosulfapyridine on trinitrobenzene‐sulphonic acid‐induced colonic damage in rats, a model representative of ulcerative colitis and Crohn's disease in man is compared.
Journal ArticleDOI
Vaginoperineal Fistula as a Complication of Perianal Surgery in a Patient with Sjögren's Syndrome: A Case Report.
TL;DR: It is believed that patients with autoimmune disorders with or without medical treatment may have healing problems during the course of surgical processes and therefore such medical problems must be taken into consideration by the surgeons.
Journal ArticleDOI
In vitro and in vivo impact of a new glycosphingolipid on neutrophils
Ezio Tubaro,C. Croce,Giorgio Cavallo,L. Belogi,G. Guida,C. Santiangeli,Maria Grazia Cifone,Angela Santoni,Fabrizio Mainiero +8 more
TL;DR: A new water-soluble, orally absorbable de-N-acetyl-lysoganglioside (WILD20), breakdown product of the monosialogangLioside GM1, was found to influence some parameters of neutrophil response to inflammation stimuli.
References
More filters
Journal ArticleDOI
A rapid method of total lipid extraction and purification.
E. G. Bligh,W. J. Dyer +1 more
TL;DR: The lipid decomposition studies in frozen fish have led to the development of a simple and rapid method for the extraction and purification of lipids from biological materials that has been applied to fish muscle and may easily be adapted to use with other tissues.
Journal ArticleDOI
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
Journal ArticleDOI
Oxygen-derived free radicals in postischemic tissue injury.
TL;DR: It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion injury, and Dysfunction induced by free radicals may be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain.