Journal ArticleDOI
Effect of hydroxyurea on the incorporation of thymidine into ehrlich ascites tumor cells.
TLDR
The antitumor agent, hydroxyurea, was shown to reduce the rate of incorporation of thymidine- 3 H into Ehrlich ascites tumor cells in vitro and this loss was not accompanied by gross cellular disorganization.About:
This article is published in Biochemical Pharmacology.The article was published on 1964-10-01. It has received 57 citations till now. The article focuses on the topics: Thymidine.read more
Citations
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Book ChapterDOI
Chemical suppression of adaptive immunity.
Ann E. Gabrielsen,Robert A. Good +1 more
TL;DR: The chapter's interpretation is based on the hypothesis that there are two functionally distinct lymphoid systems: (1) thymus dependent involved in delayed-type hypersensitivity and (2) dependent on the bursa of fabricius or its analogue in mammals involved in antibody production.
Journal ArticleDOI
Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis.
TL;DR: In cultures of exponentially growing 3T6 cells, 3 mM hydroxyurea rapidly stopped ribonucleotide reduction and DNA synthesis and, paradoxically, the pool of thymidine triphosphate increased; compartmentation of pools and/or vulnerability of newly formed DNA strands to nuclease action and pyrophosphorolysis are discussed.
Journal Article
Hydroxyurea-induced inhibition of deoxyribonucleotide synthesis: studies in intact cells.
TL;DR: Hydroxyurea-induced inhibition of thymidine incorporation by monolayers of HeLa cells was partially prevented and reversed by addition of deoxyadenosine, deoxyguanosine, and deoxycytidine to the culture medium, compatible with the postulate that this compound inhibits reduction of ribonucleotides to deoxyribon nucleotides.
Journal ArticleDOI
Studies with hydroxyurea: I. The reversible inhibition of bacterial DNA synthesis and the effect of hydroxyurea on the bactericidal action of streptomycin
TL;DR: Using hydroxyurea to inhibit the synthesis of DNA in E. coli, it could be shown that DNA synthesis is not required for the bactericidal effect of streptomycin.
References
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Journal ArticleDOI
The fine structure of the cells in mouse sarcoma 37 ascitic fluids
TL;DR: The tumour cells and the reaction cells in Sarcoma 37 ascitic fluids have been studied in thin sections with the electron microscope and it is found that the cell membrane of eosinophil granulocytes has a laminated composition and the characteristic granules of these cells a double limiting membrane.
Journal ArticleDOI
Hydroxyurea: Mechanism of Action
TL;DR: Acetohydroxamic acid has been identified, by paper chromatography, in the blood of three patients with chronic myelogenous leukemia on hydroxyurea therapy, which suggests that the drug is hydrolyzed yielding hyroxylamine, which then cleaves thioesters, in particular acetyl-coenzyme A.
Journal Article
Effect of hydroxyurea on pseudomonas aeruginosa.
TL;DR: Hydroxyurea was shown to inhibit the growth of species of Pseudomonas and inhibits cell division through interference with DNA metabolism while inhibiting cell growth to a lesser extent.