Effect of Porcine Cancellous Bones on Regeneration in Rats with Calvarial Defect
TLDR
Grafting of porcine cancellous bone was more efficient for regenerating new bone than grafting -TCP, and repair of bone defect was the least in the CD group, and significant new bone formation was observed in the PCB group.Abstract:
The purpose of this study was to evaluate the effect of porcine cancellous bone as a scaffold in a rat calvarial defect model. Critical-sized defects were created in 30 male Sprague-Dawley rats. The animals were divided into critical defect (CD, n=10), -tricalcium phosphate (TCP) graft (BT, n=10) and porcine cancellous bone graft (PCB, n=10) groups. Each defect was filled with -TCP mixed with fibrin glue or porcine cancellous bone powder mixed with fibrin glue. In the CD group, the defect was left empty. All rats were sacrificed at 8 weeks after bone graft surgery, and bone formation was evaluated by gross observation, plain radiography, micro-computed tomography scanning and histological evaluation. Repair of bone defect was the least in the CD group, and significant new bone formation was observed in the PCB group. Grafting of porcine cancellous bone was more efficient for regenerating new bone than grafting -TCP.read more
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References
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Journal ArticleDOI
Complications of Iliac Crest Bone Graft Harvesting
TL;DR: In a retrospective review of 414 consecutive cases of iliac crest bone graft procedures performed at Brooke Army Medical Center from 1983 to 1993, 41 (10%) minor and 24 (5.8%) major complications were identified.
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Autogenous Iliac Crest Bone Graft: Complications and Functional Assessment
TL;DR: The mean Sickness Impact Profile score for patients completing questionnaires was nine, suggesting most patients were functioning well 2 years postoperatively, and the morbidity of iliac crest grafting remains substantial.
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Role of bone substitutes.
TL;DR: In this review, bone substitutes are grouped into 2 categories, polymers and ceramics, and each is subclassified as biodegradable or nonbiodesgradable.
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Hydroxyapatite and tricalcium phosphate bone graft substitutes.
TL;DR: Autografts have consistently outperformed calcium phosphate implants in most experimental models and clinical applications, however, human trials in metaphyseal defects demonstrate comparable results with autograft, hydroxyapatite, and TCP.