Journal ArticleDOI
Effects of bis(benzyl)polyamine analogs on Leishmania donovani promastigotes.
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TLDR
It is concluded that the major mechanism by which bis(benzyl)polyamine analogs act may be by disruption of macromolecular biosynthesis and cell death andression of polyamines by these analogs may be yet another factor involved in slowing the growth of the parasite.About:
This article is published in Experimental Parasitology.The article was published on 1995-08-01. It has received 28 citations till now. The article focuses on the topics: Ornithine decarboxylase & Polyamine.read more
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Journal ArticleDOI
Arginine and Polyamines Fate in Leishmania Infection
Sandra Marcia Muxel,Juliana Ide Aoki,Juliane Cristina Ribeiro Fernandes,Maria Fernanda Laranjeira-Silva,Ricardo Andrade Zampieri,Stephanie Maia Acuña,Karl Erik Müller,Rubia Heloisa Vanderlinde,Lucile Maria Floeter-Winter +8 more
TL;DR: The main aspects of Leishmania-host interaction are described, focusing on the arginine and polyamines pathways and pointing to possible targets to be used for prognosis and/or in the control of the infection.
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Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities.
TL;DR: In the present review, the current knowledge of unique properties of polyamine metabolism in these parasites is outlined, including prozyme regulation of AdoMetDC (S-adenosylmethionine decarboxylase) activity in trypanosomatids, and formation of trypanothione, a unique compound linking polyamine and thiol metabolism intrypanosomeids.
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Antileishmanial activity of HIV protease inhibitors
TL;DR: New in vitro insights into the wide-spectrum efficacy of PI are added and it is suggested that studying their action on amastigote forms of leishmania within macrophages in order to validate their potential contribution against opportunistic infections in treated seropositive patients is suggested.
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Polyamine transport in parasites: A potential target for new antiparasitic drug development
TL;DR: This review contains information on the polyamine requirements and molecular, biochemical and genetic characterization of different transport mechanisms in the parasitic agents responsible for a number of the deadly diseases that afflict underdeveloped and developing countries.
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The putrescine analogue 1,4-diamino-2-butanone affects polyamine synthesis, transport, ultrastructure and intracellular survival in Leishmania amazonensis.
TL;DR: Results suggest that putrescine may be involved in leishmanial survival, possibly by maintaining the parasite's mitochondrial function, and the use of analogues to interfere with polyamine/diamine synthesis and transport may shed light on its function in intracellular parasite survival and lead to identification of new targets forLeishmaniasis chemotherapy.