Journal ArticleDOI
Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea.
Luciano F. Drager,Luiz Aparecido Bortolotto,Adelaide C. Figueiredo,Eduardo M. Krieger,Geraldo Filho Lorenzi +4 more
TLDR
The treatment of OSA significantly improves early signs of Atherosclerosis, supporting the concept that OSA is an independent risk factor for atherosclerosis.Abstract:
Rationale: Obstructive sleep apnea (OSA) is associated with adverse cardiovascular outcomes, including myocardial infarction and stroke. Atherosclerosis is a key mechanism for these cardiovascular events. Recent cross-sectional studies showed the presence of early signs of atherosclerosis in patients with OSA who were free of comorbidities.Objectives: To determine the impact of treatment with continuous positive airway pressure (CPAP) on atherosclerosis.Methods: We randomly assigned 24 patients with severe OSA (age, 46 ± 6 yr) who were free of comorbidities to receive no treatment (control, n = 12) or CPAP (n = 12) for 4 months. Carotid intima-media thickness, arterial stiffness (evaluated by pulse-wave velocity), carotid diameter, 24-hour blood pressure monitoring, C-reactive protein, and catecholamines were determined at baseline and after 4 months.Measurements and Main Results: At baseline, all measurements were similar in both groups and did not change in the control group after 4 months. In contrast,...read more
Citations
More filters
Journal ArticleDOI
Pathophysiology of Sleep Apnea
TL;DR: This work reviews three types of major long-term sequelae to severe OSA and discusses future research into understanding the pathophysiology of sleep apnea as a basis for uncovering newer forms of treatment of both the ventilatory disorder and its multiple sequelae.
Journal ArticleDOI
Obstructive sleep apnoea and its cardiovascular consequences
TL;DR: Current data suggest that OSA increases the risk of developing cardiovascular diseases, and that its treatment has the potential to diminish such risk, but large-scale randomised trials are needed to determine, definitively, whether treating OSA improves cardiovascular outcomes.
Journal ArticleDOI
Sleep Apnea and Cardiovascular Disease
Virend K. Somers,David P. White,Raouf S. Amin,William T. Abraham,Fernando Ferreira Costa,Antonio Culebras,Stephen R. Daniels,John S. Floras,Carl E. Hunt,Lyle J. Olson,Thomas G. Pickering,Richard O. Russell,Mary Woo,Terry Young +13 more
TL;DR: The American Heart Association/American College of Cardiology Scientific Statement on Sleep Apnea and Cardiovascular Disease as discussed by the authors highlights concepts and evidence important to understanding the interactions between sleep apnea and cardiovascular disease, with particular attention to more recent advances in patient-oriented research.
Journal ArticleDOI
Management of Obstructive Sleep Apnea in Adults: A Clinical Practice Guideline From the American College of Physicians
TL;DR: This guideline grades the evidence and recommendations using ACP's clinical practice guidelines grading system and recommends that all overweight and obese patients diagnosed with OSA should be encouraged to lose weight.
Journal ArticleDOI
Health outcomes of continuous positive airway pressure versus oral appliance treatment for obstructive sleep apnea: a randomized controlled trial.
Craig L. Phillips,Ronald R. Grunstein,M. Ali Darendeliler,Anastasia S. Mihailidou,Vasantha K. Srinivasan,Brendon J. Yee,Guy B. Marks,Peter A. Cistulli +7 more
TL;DR: Important health outcomes were similar after 1 month of optimal MAD and CPAP treatment in patients with moderate-severe OSA, although MAD was superior to CPAP for improving four general quality-of-life domains.
References
More filters
Journal ArticleDOI
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.
Aram V. Chobanian,George L. Bakris,Henry R. Black,William C. Cushman,Lee A. Green,Joseph L. Izzo,Daniel W. Jones,Barry J. Materson,Suzanne Oparil,Jackson T. Wright,Edward J. Roccella +10 more
TL;DR: The most effective therapy prescribed by the most careful clinician will control hypertension only if patients are motivated, and empathy builds trust and is a potent motivator.
Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
Aram V. Chobanian,George L. Bakris,Henry R. Black,William C. Cushman,Lee A. Green,Joseph L. Izzo,Daniel W. Jones,Barry J. Materson,Suzanne Oparil,Jackson T. Wright,Edward J. Roccella +10 more
TL;DR: In those older than age 50, systolic blood pressure of greater than 140 mm Hg is a more important cardiovascular disease (CVD) risk factor than diastolic BP, and hypertension will be controlled only if patients are motivated to stay on their treatment plan.
Journal ArticleDOI
A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
TL;DR: The development and use of a new scale, the Epworth sleepiness scale (ESS), is described, which is a simple, self-administered questionnaire which is shown to provide a measurement of the subject's general level of daytime sleepiness.
Journal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
TL;DR: Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.