Institution
Toronto Rehabilitation Institute
Healthcare•Toronto, Ontario, Canada•
About: Toronto Rehabilitation Institute is a healthcare organization based out in Toronto, Ontario, Canada. It is known for research contribution in the topics: Population & Rehabilitation. The organization has 1311 authors who have published 2882 publications receiving 85253 citations. The organization is also known as: Toronto Rehab.
Papers published on a yearly basis
Papers
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TL;DR: Overall survival was slightly better in patients who had preoperative radiotherapy than in those who had postoperative treatment, and the size and anatomical site of the tumour was also significant risk factors in multivariate analysis.
1,277 citations
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TL;DR: Current data suggest that OSA increases the risk of developing cardiovascular diseases, and that its treatment has the potential to diminish such risk, but large-scale randomised trials are needed to determine, definitively, whether treating OSA improves cardiovascular outcomes.
1,214 citations
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TL;DR: It is concluded that historical information, supplemented by a few simple laboratory tests may enable physicians to risk stratify CHF patients for the presence of CSA or OSA, and the need for diagnostic polysomnography for such patients.
Abstract: In previous analyses of the occurrence of central (CSA) and obstructive sleep apnea (OSA) in patients with congestive heart failure (CHF), only men were studied and risk factors for these disorders were not well characterized. We therefore analyzed risk factors for CSA and OSA in 450 consecutive patients with CHF (382 male, 68 female) referred to our sleep laboratory. Risk factors for CSA were male gender (odds ratio [OR] 3.50; 95% confidence interval [CI], 1.39 to 8.84), atrial fibrillation (OR 4.13; 95% CI 1.53 to 11. 14), age > 60 yr (OR 2.37; 95% CI 1.35 to 4.15), and hypocapnia (PCO(2 ) 35 kg/m(2), 6.10; 95% CI 2.86 to 13.00); whereas, in women, age was the only important risk factor (OR for age > 60 yr, 6.04; 95% CI 1.75 to 20.0). We conclude that historical information, supplemented by a few simple laboratory tests may enable physicians to risk stratify CHF patients for the presence of CSA or OSA, and the need for diagnostic polysomnography for such patients. Sin DD, Fitzgerald F, Parker JD, Newton G, Floras JS, Bradley TD. Risk factors for central and obstructive sleep apnea in 450 men and women with congestive heart failure.
1,078 citations
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TL;DR: In medically treated patients with heart failure, treatment of coexisting obstructive sleep apnea by continuous positive airway pressure reduces systolic blood pressure and improves left ventricular syStolic function.
Abstract: Background Obstructive sleep apnea subjects the failing heart to adverse hemodynamic and adrenergic loads and may thereby contribute to the progression of heart failure. We hypothesized that treatment of obstructive sleep apnea by continuous positive airway pressure in patients with heart failure would improve left ventricular systolic function. Methods Twenty-four patients with a depressed left ventricular ejection fraction (45 percent or less) and obstructive sleep apnea who were receiving optimal medical treatment for heart failure underwent polysomnography. On the following morning, their blood pressure and heart rate were measured by digital photoplethysmography, and left ventricular dimensions and left ventricular ejection fraction were assessed by echocardiography. The subjects were then randomly assigned to receive medical therapy either alone (12 patients) or with the addition of continuous positive airway pressure (12 patients) for one month. The assessment protocol was then repeated. Results In...
1,007 citations
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TL;DR: A lack of examination of how and why the excess costs were being accrued appeared to be a commonality between most studies, and future studies must better explore how costs accrue among obese populations, in order to best facilitate health and social policy interventions.
Abstract: In the last decade, the prevalence of obesity has increased significantly in populations worldwide. A less dramatic, but equally important increase has been seen in our knowledge of its effects on health and the burden it places on healthcare systems. This systematic review aims to assess the current published literature on the direct costs associated with obesity. A computerized search of English language articles published between 1990 and June 2009 yielded 32 articles suitable for review. Based on these articles, obesity was estimated to account for between 0.7% and 2.8% of a country's total healthcare expenditures. Furthermore, obese individuals were found to have medical costs that were approximately 30% greater than their normal weight peers. Although variations in inclusion/exclusion criteria, reporting methods and included costs varied widely between the studies, a lack of examination of how and why the excess costs were being accrued appeared to be a commonality between most studies. Accordingly, future studies must better explore how costs accrue among obese populations, in order to best facilitate health and social policy interventions.
913 citations
Authors
Showing all 1334 results
Name | H-index | Papers | Citations |
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Leonardo G. Cohen | 131 | 426 | 61793 |
Michael G. Fehlings | 116 | 1189 | 57003 |
Sandra E. Black | 104 | 681 | 51755 |
Roy J. Shephard | 91 | 840 | 38147 |
David Henry | 89 | 547 | 45563 |
Muhammad Mamdani | 83 | 441 | 28319 |
Donna E. Stewart | 80 | 428 | 24175 |
Christine M. Friedenreich | 79 | 383 | 23097 |
Paula A. Rochon | 75 | 367 | 19524 |
Aileen M. Davis | 74 | 320 | 20526 |
Robert Teasell | 73 | 357 | 19107 |
Don D. Sin | 70 | 155 | 39570 |
Dina Brooks | 69 | 419 | 18637 |
William E. McIlroy | 66 | 234 | 14519 |
Joel Katz | 66 | 288 | 20507 |