Journal ArticleDOI
Effects of Dopamine Infusion on Pituitary Hormone Secretion in Humans
TLDR
Dopamine infusion induced a prompt and sustained suppression of circulating prolactin levels in normal men and women as well as in patients with hyperprolactinemia, indicating that in man a dopaminergic mechanism ixists in the regulation of PRL secretion and that dopamine also exerts an inhibitory effect of LH release.Abstract:
Dopamine, infused at a rate of 4 mug/kg/min for 3-4 h unaccompanied by any significant changes in cardiovascular dynamics, induced a prompt and sustained suppression of circulating prolactin (PRL) levels in normal men and women as well as in patients with hyperprolactinemia At the discontinuation of the infusion, there was a marked rebound in PRL levels in normal subjects and a rapid return to basal levels in hyperprolactinemic patients Dopamine infusion also induced a significant fall in LH levels in the normal subjects with a marked rebound in LH levels following the infusion No significant changes in GH, TSH, and FSH levels were observed These data indicate that in man a dopaminergic mechanism ixists in the regulation of PRL secretion and that dopamine also exerts an inhibitory effect of LH releaseread more
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in Women with
TL;DR: Basal and post-stimulation prolactin levels were correlated with estradiol levels and the hypothesis that central dopaminergic inhibition is related to diminished LH release in this state of anorexia nervosa was supported.
Journal ArticleDOI
Reproductive endocrine disorders in women with partial seizures of temporal lobe origin.
Andrew G. Herzog,Machelle M. Seibel,Donald L. Schomer,Judith L. Vaitukaitis,Norman Geschwind +4 more
TL;DR: Twenty consecutive men with partial seizures of temporal lobe origin were evaluated for sexual or reproductive dysfunction, andEleven of them had diminished sexual interest or reduced potency.
Journal ArticleDOI
Blood Hormones as Markers of Training Stress and Overtraining
TL;DR: An intraindividually decreased maximum rise of pituitary hormones (corticotrophin, growth hormone, cortisol and insulin has been found after a standardised exhaustive exercise test performed with an intensity of 10% above the individual anaerobic threshold, suggesting an impaired hypothalamic regulation.
Journal ArticleDOI
Neuroendocrine aberrations in women with functional hypothalamic amenorrhea.
TL;DR: Pituitary hormone increments in response to the simultaneous iv administration of GnRH, CRH, GHRH, and TRH were similar in the two groups, except for a blunted PRL response to TRH in the women with FHA (P less than 0.05).
Journal ArticleDOI
Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illness.
TL;DR: The results of these studies support the hypothesis that there is defective noradrenergic function in the brains of some patients with depressive illness.
References
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Journal ArticleDOI
Studies on the mechanism of the dopamine-mediated inhibition of prolactin secretion.
TL;DR: Apomorphine, an agent known to mimic the effects of dopamine, caused a significant decrease in the amount of radioactive and radioimmunoassayable prolactin released int...
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Simplified, partially automated method for radioimmunoassay of human thyroid-stimulating, growth, luteinizing, and follicle stimulating hormones.
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Disappearance rates of endogenous luteinizing hormone and chorionic gonadotropin in man.
TL;DR: Assessment of the rates of disappearance of endogenous LH and HCG from serum following complete surgical hypophysectomy and removal of the placenta found that the disappearance rates appear to follow a double exponential curve although there may be a possible additional exponential.
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Cyproheptadine-induced remission of Cushing's disease.
TL;DR: Experimental evidence suggests a Central-nervous-system origin of Cushing's disease and a role for serotonin in the regulation of ACTH release and the efficacy of cyproheptadine therapy.
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The role of catecholamines in the release of anterior pituitary prolactin in vitro.
TL;DR: In all cases rat hypothalamic extracts significantly inhibited pituitary prolactin (PRL) release in vitro and the catecholamine containing acid eluate from the alumina adsorption procedure was able to inhibit PRL release to the same degree as untreated hypothalamic extract.