Journal ArticleDOI
Effects of indirectly acting 5-HT receptor agonists on circulating melatonin levels in rats
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TLDR
The results of this study suggest that the rate of pineal melatonin synthesis is dependent on the free cytoplasmic pool of 5-HT in pinealocytes and that the drug-induced elevation of this pool stimulates melatonin formation and increases circulating melatonin levels.About:
This article is published in European Journal of Pharmacology.The article was published on 1993-07-20. It has received 30 citations till now. The article focuses on the topics: Melatonin & Pinealocyte.read more
Citations
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Journal ArticleDOI
Suppression of aggression in rainbow trout (Oncorhynchus mykiss) by dietary l-tryptophan
TL;DR: Juvenile rainbow trout Oncorhynchus mykiss were isolated in individual compartments in observation aquaria and allowed to acclimate for 1 week, and it is suggested that the suppressive effect of dietary L-tryptophan on aggressive behaviour is mediated by an elevation of brain serotonergic activity.
Journal ArticleDOI
Pain in the brain: are hormones to blame?
TL;DR: Specific targeting of hormonal cascade and effector mechanisms could provide an alternative strategy for the treatment of various chronic pain conditions.
Journal ArticleDOI
Effect of orally administered L-tryptophan on serotonin, melatonin, and the innate immune response in the rat.
Susana Esteban,Cristina Nicolaus,Antonio Garmundi,Rubén V. Rial,Ana Rodríguez,Eduardo Ortega,Carmen Barriga Ibars +6 more
TL;DR: The results indicated that the synthesis of serotonin and melatonin, as well as the innate immune response, can be modulated by oral ingestion of tryptophan.
Journal Article
Gastrointestinal melatonin: cellular identification and biological role.
Igor M. Kvetnoy,Irina E Ingel,T. V. Kvetnaia,Malinovskaya Nadezhda K,Rapoport Semen I,N. T. Raikhlin,Alexander V Trofimov,V. V. Yuzhakov +7 more
TL;DR: The role of melatonin in gastrointestinal functions is considered and a major source of extrapineal melatonin is the gastrointestinal tract.
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Circadian Levels of Serotonin in Plasma and Brain after Oral Administration of Tryptophan in Rats
TL;DR: Oral administration of tryptophan during 7 days enhances serotonin levels over a 24-hr period, and produces an advance in the peak of serotonin in both plasma and different brain regions.
References
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Journal ArticleDOI
Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N-Acetyltransferase
David C. Klein,Joan L. Weller +1 more
TL;DR: Experiments in vitro indicate that norepinephrine, not serotonin, regulates the activity of N-acetyl-transferase through a highly specific receptor.
Journal Article
Luzindole (N-0774) : a novel melatonin receptor antagonist
TL;DR: The data suggest that luzindole and the various melatonin agonists are competing for the same presynaptic melatonin receptor site in the rabbit retina.
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Melatonin binding sites in the central nervous system.
TL;DR: Central nervous system binding sites (receptors) for melatonin and CorticaI structures in the anterior hypothalamus and other areas are studied.
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Melatonin and psychiatry
TL;DR: Present ideas suggest a positive involvement of melatonin in affective disorders, possible involvement in the schizophrenic psychosis, and potential involvement of this hormone in other psychiatric categories.
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Melatonin inhibits cyclic AMP and cyclic GMP accumulation in the rat pituitary.
Jiří Vaněček,Lutz Vollrath +1 more
TL;DR: Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-Hormone.