Journal ArticleDOI
Melatonin and psychiatry
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TLDR
Present ideas suggest a positive involvement of melatonin in affective disorders, possible involvement in the schizophrenic psychosis, and potential involvement of this hormone in other psychiatric categories.About:
This article is published in Biological Psychiatry.The article was published on 1988-02-15. It has received 130 citations till now. The article focuses on the topics: Melatonin.read more
Citations
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Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin.
TL;DR: Results show that calmodulin appears to be involved in this process because its presence in the incubation medium was able to prevent the effect of melatonin on both NOS activity and cyclic GMP production, and polyacrylamide gel electrophoresis studies suggest that melatonin can interact with Calmodulin modifying the binding of the peptide to the synthetic NOS peptide.
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Effect of tryptophan administration on circulating melatonin levels in chicks and rats: evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract.
TL;DR: The possibility is discussed that the sedating, sleep inducing effects of Trp are mediated by the Trp-induced elevation of circulating melatonin.
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Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum.
TL;DR: Results suggest a new and important role of the pineal hormone melatonin on central nervous system processes, i.e., by modulating NO production.
Journal ArticleDOI
Melatonin in mood disorders
Venkataramanujan Srinivasan,Marcel Smits,Warren Spence,Alan D. Lowe,Leonid Kayumov,Seithikurippu R. Pandi-Perumal,Barbara L. Parry,Daniel P. Cardinali +7 more
TL;DR: The role of melatonin in the pathophysiology of bipolar disorder and SAD is discussed and bright light treatment, that suppresses melatonin production, is effective in treating bipolar affective disorder andSAD, winter type.
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Melatonin reduces nitric oxide synthase activity in rat hypothalamus
Ilham Bettahi,David Pozo,Carmen Osuna,Russel J. Reiter,Darío Acuña-Castroviejo,Juan M. Guerrero +5 more
TL;DR: In vitro studies demonstrate that 1 nM melatonin, which approximates the physiological concentration of the hormone at night, significantly inhibited NOS activity, and results show that calmodulin may be involved in this process since its presence in the incubation medium prevents the inhibitory effect of melatonin on Nos activity.
References
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The catecholamine hypothesis of affective disorders: a review of supporting evidence
TL;DR: The "catecholamine hypothesis of affective disorders" as discussed by the authors suggests that depression is associated with an absolute or relative decrease in catecholamines, particularly norepinephrine, available at central adrenergic receptor sites.
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Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
TL;DR: Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding, providing a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.
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Isolation of melatonin, the pineal gland factor that lightens melanocytes1
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The Pineal and Its Hormones in the Control of Reproduction in Mammals
TL;DR: By the usual criteria in endocrinology, the pineal now fulfills all the qualifications of an organ of internal secretion.