Effects of lead acetate on testicular function and caspase-3 expression with respect to the protective effect of cinnamon in albino rats.
TLDR
Cinnamon exhibited protective effect on reproductive system by inhibiting lead acetate induced oxidative stress and excessive cell apoptosis and improved the level of SOD and catalase activities in male rats.Abstract:
The aim of this study was to investigate the protective effects of cinnamon on lead acetate induced reproductive toxicities in rats. Thirty-two male rats were randomly divided into 4 groups, 8 rats in each. Control rats received distilled water, while treated rats received lead acetate (30 mg/kg), cinnamon (250 mg/kg) and lead acetate and cinnamon (30 mg/kg and 250 mg/kg) for 60 days by gavage tube. In cinnamon treated rats, the relative weights of testes, epididymis, seminal and prostate glands were significantly (P < 0.05) increased compared with that in lead acetate treated rats. Sperm cell concentration and viability were significantly (P < 0.05) reduced, while sperm abnormalities were significantly (P < 0.05) increased in lead treated rats. The superoxide dismutase (SOD) and catalase activities were significantly reduced (P < 0.001) in lead acetate treated rats compared to the other groups, while the addition of cinnamon to lead acetate improved the level of SOD compared to the lead treated group. There was a marked reduction (P < 0.001) in the expression of androgen receptor and significant (P < 0.001) increase in the level of caspase-3 protein expression in the testis of lead treated rats. In conclusion, cinnamon exhibited protective effect on reproductive system by inhibiting lead acetate induced oxidative stress and excessive cell apoptosis.read more
Citations
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Journal ArticleDOI
The Detrimental Effects of Lead on Human and Animal Health
Mohammed Abdulrazzaq Assi,Mohd Noor Mohd Hezmee,Abd Wahid Haron,Mohd Yusof Mohd Sabri,Mohd Ali Rajion +4 more
TL;DR: The massive harmful impact that leads acetate toxicity has on the animals and the worrying fact that this harmful toxicant can be found quite easily in the environment and abundance are discussed.
Journal ArticleDOI
Carnosine and Histidine Supplementation Blunt Lead-Induced Reproductive Toxicity through Antioxidative and Mitochondria-Dependent Mechanisms.
Mohammad Mehdi Ommati,Mohammad Mehdi Ommati,Akram Jamshidzadeh,Reza Heidari,Zilong Sun,Mohammad Javad Zamiri,Forouzan Khodaei,Saeed Mousapour,Fatemeh Ahmadi,Nafiseh Javanmard,Babak Shirazi Yeganeh +10 more
TL;DR: It was found that carnosine and HIS supplementation blunted the Pb-induced oxidative stress and mitochondrial dysfunction in the rat reproductive system, and antioxidative and mitochondria-protective properties serve as primary mechanisms for CAR and HIS against P b-induced reproductive toxicity.
Journal ArticleDOI
Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review.
TL;DR: In vitro and animal studies consider the antidotal and/or protective effects of cinnamon and its major constituents against natural toxins and chemical-induced toxicities.
Journal ArticleDOI
Ameliorating effects of green tea extract on cadmium induced reproductive injury in male Wistar rats with respect to androgen receptors and caspase- 3.
TL;DR: GTE exhibited protective effect on testes by inhibiting CdCl2 induced oxidative damage and cellular apoptosis, and showed marked reduction and increase inesticular androgen receptors and caspase-3 protein expression.
Journal ArticleDOI
A potential mechanism associated with lead-induced testicular toxicity in rats.
Mohammed A. El-Magd,Khaled A. Kahilo,Nasr Elsayed Nasr,Tarek Kamal,Mustafa Shukry,Ayman A. Saleh +5 more
TL;DR: Pb induces testicular oxidative damage and disrupts spermatogenesis, at least in part, via downregulation of Cyp19 and ERα expression, which further decrease E2 level, and insight into the mechanism of lead‐induced testicular toxicity is provided.
References
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