Journal ArticleDOI
Effects of Melatonin and an Aqueous Pineal Extract on Adrenal Secretion of Reduced Steroid Metabolites in Female Rats
T.F. Ogle,J.I. Kitay +1 more
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TLDR
It is suggested that melatonin is a potential contributor to the physiologic regulation of adrenal steroidogenesis and an aqueous extract of bovine pineal glands on adrenal function were studied.Abstract:
The effects of melatonin and an aqueous extract of bovine pineal glands on adrenal function were studied in pinealectomized, ovariectomized and hypophysectomized rats. Melatonin (50 µg i.p., twice daily for 1 week) stimulates adrenal 5α-reductase activity in intact animals and after ovariectomy. A corresponding enhancement in the secretion of the principal 5α-reduced metabolites of corticosterone (B), dihydrocorticosterone (DHB) and tetrahydrocorticosterone (THB), occurs in vivo. As a result, proportional output of B declines. In contrast, an aqueous pineal extract (360 mg bovine pineal tissue/day for 1 week) fails to alter reductase activity or to produce the secretory changes associated with increased reductive metabolism of B. Melatonin also stimulates adrenal reductase activity in hypophysectomized rats. The results suggest that melatonin is a potential contributor to the physiologic regulation of adrenal steroidogenesis.read more
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Melatonin and psychiatry
TL;DR: Present ideas suggest a positive involvement of melatonin in affective disorders, possible involvement in the schizophrenic psychosis, and potential involvement of this hormone in other psychiatric categories.
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Melatonin: a rediscovered antitumor hormone? Its relation to surface receptors; sex steroid metabolism, immunologic response, and chronobiologic factors in tumor growth and therapy.
William Regelson,W. Pierpaoli +1 more
TL;DR: Recent observations suggest that melatonin deserves clinical trial to enhance or modify response in hormonally sensitive tumors and to determine if melatonin’s impact on chronobiologic control can improve the circadian rhythm.
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An in vitro stimulatory effect of indoleamines on aldosterone biosynthesis in the rat.
TL;DR: The results suggest that pineal indoles could play a role in aldosterone biosynthesis and indicate that changes in sodium balance affect the a Aldosterone response to indoles in the same way as has been described for other ald testosterone secretagogues.
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Sex-dependent effect of melatonin on the secretory activity of rat and hamster adrenal gland in vitro.
TL;DR: Melatonin did not change cortisol output by adrenals obtained from the male hamsters, while a slight stimulatory effect was observed in female glands, the lower concentration of melatonin being more effective than the higher one, and the modulatory effect ofmelatonin of the secretion of steroid hormones is more effective at lower concentrations.
Journal ArticleDOI
Activity of melatonin and other pineal indoles on the in vitro synthesis of cortisol, cortisone, and adrenal androgens.
TL;DR: This work demonstrates the activating effect of some indole compounds on 11 β‐hydroxylase and 17,20‐desmolase and the inhibitory effect of most of them on 11β‐hydroxysteroid dehydrogenase.