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Effects of metal protoporphyrins on burn wound conversion
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These studies demonstrate proof in principal that pharmacologic activity of heavy metal protoporphyrins on burn wound conversion is safe and effective.Abstract:
EFFECTS OF METAL PROTOPORPHYRINS ON BURN WOUND CONVERSION By Katie Lynne Braun, M.S. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University. Virginia Commonwealth University, 2008 Major Director: Dorne R. Yager, Ph. D. Associate Professor & Director of Research, Department of Surgery A murine model was utilized to test the influence of heavy metal protoporphyrins on burn conversion, heme oxygenase – 1 (HO-1) expression, and inflammation. Heavy metal protoporphyrins, such as cobalt protoporphyrin (Co PP) and tin protoporphyrin (Sn PP), were used to influence the heme oxygenase activity. The effects of these heavy metal protoporphyrins on burn wound conversion were examined using a burn comb model in rats. In addition to assessing the extent of conversion, HO-1 expression and parameters of inflammation were also examined in the area of injury (interspace region) subject to conversion. These studies demonstrate proof in principal that pharmacologicread more
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Journal ArticleDOI
The pathogenesis of burn wound conversion
TL;DR: Burn wound progression is complex and caused by additive effects of inadequate tissue perfusion, free radical damage, and systemic alterations in the cytokine milieu of burn patients, leading to protein denaturation and necrosis.
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