Journal ArticleDOI
Effects of sex hormones on diet‐induced atrial thrombosis
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Male and female Taconic Swiss mice were fed a high‐fat (28%), low‐protein (8%), hypolipotropic diet and without injections of estrone or testosterone phenylacetate were studied.Abstract:
Male and female Taconic Swiss mice were fed a high-fat (28%), low-protein (8%), hypolipotropic diet. Intact mice and gonadectomized mice, with and without injections of estrone or testosterone phenylacetate were studied.
The sex of the animals did not alter the incidence or type of diet-induced cardiovascular lesions. During the 6–12 weeks of feeding thrombi developed in the atrial lumina of 75%–88% of intact and gonadectomized male and female mice. The only prominent decrease in the incidence of such thrombosis was in gonadectomized animals of both sexes receiving estrone where it was reduced to 6%–16%. In castrated males receiving injections of testosterone phenylacetate (Perandren) the incidence of thrombosis was 65%.read more
Citations
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TL;DR: The present review shows clearly that the spectrum of myocardial diseases in animals is enlarging and that many newly recognized diseases are emerging and assuming considerable importance.
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Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank.
TL;DR: Endogenous testosterone was positively associated with thromboembolism, heart failure, and myocardial infarction in men and could be a modifiable risk factor for thrombinolism and heart failure.
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Transplantation of young ovaries restored cardioprotective influence in postreproductive-aged mice
Jeffrey B. Mason,Shelley L. Cargill,Stephen M Griffey,J. Rachel Reader,Gary B. Anderson,James R. Carey +5 more
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Book ChapterDOI
Life-Span, Hematological Abnormalities, Thrombosis and Other Macroscopical Lesions in the Spontaneously Hypertensive Rats
Book ChapterDOI
Atrial Thrombosis, Rat, Mouse, and Hamster
TL;DR: Rodents with atrial thrombosis can be recognized at necropsy and associated lesions in hamsters include pulmonary edema and pleural effusion.
References
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The Inhibition of Coronary Atherosclerosis by Estrogens in Cholesterol-Fed Chicks
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Michael F. Oliver,G. S. Boyd +1 more
TL;DR: Assessment of the effect of ethinyl estradiol on human atherogenesis must depend on long-term evaluation of its influence on morbidity and mortality rates.