Journal ArticleDOI
Effects of treatment with recombinant human growth hormone on insulin sensitivity and glucose metabolism in adults with growth hormone deficiency
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TLDR
During long-term treatment, the present study suggests that the change in insulin action can be reversed, probably secondarily to changes in body composition.Abstract:
In a double-blind, cross-over, placebo-controlled trial, the effect of 26 weeks of replacement therapy with recombinant human growth hormone (rhGH) on insulin sensitivity and glucose metabolism in nine patients with adult-onset growth hormone deficiency was studied with a euglycemic clamp. Glucose production and utilization were studied with d-(3-3H)-glucose infusions. Comparisons were made with placebo treatment for 6 and 26 weeks, respectively. GH therapy for 6 weeks increased fasting plasma concentrations of glucose and insulin. However, after 26 weeks of GH treatment, no significant changes in glucose or insulin concentrations were recorded. GH treatment induced a marked change in insulin action evident after 6 weeks of therapy as shown by lower glucose infusion rates (GIRs) during the clamp compared with placebo treatment (2.6 ± 0.4 v 4.1 ± 0.7 mg · kg−1 · min−1). This change in insulin action was due to a decreased insulin effect on glucose utilization. After 26 weeks of GH therapy, there was no significant difference in GIRs. During placebo treatment, insulin sensitivity and insulin, glucose, and nonesterified fatty acid (NEFA) concentrations were unchanged compared with concentrations measured before the study. Thus GH replacement therapy induces a change in insulin action in GH-deficient individuals. Whether this change represents a decrease in insulin action (ie, insulin resistance) or a restoration of action to normal is presently unclear, since a healthy control group was not included in the study. During long-term treatment, the present study suggests that the change in insulin action can be reversed, probably secondarily to changes in body composition.read more
Citations
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Journal ArticleDOI
Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review
Journal ArticleDOI
Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects.
TL;DR: The ability of GH to induce insulin resistance is significant for the defense against hypoglycemia, for the development of "stress" diabetes during fasting and inflammatory illness, and perhaps for the "Dawn" phenomenon (the increase in insulin requirements in the early morning hours).
Journal ArticleDOI
Growth hormone and the heart.
TL;DR: Evidence from laboratory models shows that GH induces mRNA expression for specific contractile proteins and myocyte hypertrophy, which provides plausible explanations for the cardiac abnormalities observed in clinical settings of excessive or defective GH production and support a role of GH in the maintenance of a normal cardiac structure and performance.
Journal ArticleDOI
Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions A Scientific Statement From the American Heart Association
Steven E. Lipshultz,M. Jacob Adams,Steven D. Colan,Louis S. Constine,Eugene H. Herman,Daphne T. Hsu,Melissa M. Hudson,Leontien C. M. Kremer,David C. Landy,Tracie L. Miller,Kevin C. Oeffinger,David N. Rosenthal,Craig Sable,Stephen E. Sallan,Gautam K. Singh,Julia Steinberger,Thomas R. Cochran,James D. Wilkinson +17 more
TL;DR: The number of childhood cancer survivors is expected to increase as a result of the rising pediatric cancer incidence and improved long-term survival rates and the Childhood Cancer Survivor Study has improved the understanding of the long- term mortality and morbidity in this high-risk population.
Journal ArticleDOI
Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure.
Gudmundur Johannsson,Per Mårin,Lars Lönn,Malin Ottosson,Kaj Stenlöf,Per Björntorp,Lars Sjöström,Bengt-Åke Bengtsson +7 more
TL;DR: It is demonstrated that GH can favorably affect some of the multiple perturbations associated with abdominal/visceral obesity, an improved insulin sensitivity, and favorable effects on lipoprotein metabolism and diastolic blood pressure.
References
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A Simple Sequentially Rejective Multiple Test Procedure
TL;DR: In this paper, a simple and widely accepted multiple test procedure of the sequentially rejective type is presented, i.e. hypotheses are rejected one at a time until no further rejections can be done.
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The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
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Journal ArticleDOI
The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency
TL;DR: It is concluded that growth hormone has a role in the regulation of body composition in adults, probably through its anabolic and lipolytic actions.
Journal ArticleDOI
Treatment of adults with growth hormone (GH) deficiency with recombinant human GH.
Bengt-Åke Bengtsson,Staffan Edén,Lars Lönn,Henry Kvist,A. Stokland,Göran Lindstedt,Ingvar Bosaeus,J. Tölli,Lars Sjöström,Olle Isaksson +9 more
TL;DR: The results show that GH replacement in GHD adults results in marked alterations in body composition, fat distribution, and bone and mineral metabolism and reduces psychiatric symptoms.
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