Journal ArticleDOI
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
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This article is published in The Lancet.The article was published on 1963-04-13. It has received 5020 citations till now. The article focuses on the topics: Randle cycle & Insulin resistance.read more
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How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
TL;DR: This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
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The metabolic syndrome
TL;DR: The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated, and a proinflammatory state probably contributes to the metabolic syndrome.
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Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Bo Isomaa,Peter Almgren,Tiinamaija Tuomi,Björn Forsén,Kaj Lahti,Michael Nissén,Marja-Riitta Taskinen,Leif Groop +7 more
TL;DR: The WHO definition of the metabolic syndrome identifies subjects with increased cardiovascular morbidity and mortality and offers a tool for comparison of results from diferent studies.
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Mechanisms linking obesity to insulin resistance and type 2 diabetes
TL;DR: In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insulin resistance.
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Cellular mechanisms of insulin resistance
TL;DR: It is shown that commonly accepted models that attempt to explain the association of insulin resistance and obesity are incompatible with recent findings and an alternative model is proposed that appears to fit these and other available data.
References
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Journal ArticleDOI
A relation between non-esterified fatty acids in plasma and the metabolism of glucose
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Unesterified fatty acid in human blood plasma
Robert S. Gordon,Amelia Cherkes +1 more
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Phosphofructokinase and the Pasteur effect.
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A rapid enzymatic assay for glycerol.
P. B. Garland,P. J. Randle +1 more
TL;DR: An alternative and more rapid method has been developed which is based on the following reactions: glycerol + ATP + L-glycerol 1-phosphate + ADP (glycersol kinase) ADP + phosphoenolpyruvate + NADH2 (lactate dehydrogenase)
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Fatty Acid and Glucose Metabolism in the Perfused Heart
TL;DR: The results indicate the readiness with which the myocardium utilizes both glucose and fatty acids, and suggest that fatty acids are preferentially oxidized.