Effects of varicocele on male fertility
Reads0
Chats0
TLDR
There appears to be a significant difference between adults and adolescents with respect to a progressive deterioration of semen parameters and it is clear that subclinical varicoceles do not play a major role in male infertility.Abstract:
Varicoceles are vascular lesions of the pampiniform plexus and are the most common identifiable abnormality found in men being evaluated for infertility. Despite the long history associated with varicoceles, there remains much controversy regarding their diagnosis and management. The purpose of this manuscript is to address three of the most pressing controversies: (i) the association of varicoceles with male infertility, (ii) whether varicoceles exert a progressive deleterious effect and (iii) the relationship of varicocele size and outcome following varicocele repair. The current literature is reviewed in an effort to answer these questions. Based upon this analysis, conclusions can be drawn regarding the best management of varicoceles in subfertile men, adolescents, young fertile men and men with subclinical varicoceles. Although there remain many controversies due to a paucity of data, there appears to be a significant difference between adults and adolescents with respect to a progressive deterioration of semen parameters and it is clear that subclinical varicoceles do not play a major role in male infertility.read more
Citations
More filters
Journal ArticleDOI
Increased sperm DNA damage in patients with varicocele: relationship with seminal oxidative stress
Rosita Smith,Heidy Kaune,Daniela Parodi,Marcia Madariaga,Rafael Ríos,Ignacio Morales,Andrea Castro +6 more
TL;DR: The results indicate that oxidative damage is associated with sperm DNA damage in patients with varicocele and that high levels of DNA-damage spermatozoa even in the presence of normal semen profile are found.
Journal ArticleDOI
Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts.
Margus Punab,Olev Poolamets,P. Paju,Vladimir Vihljajev,Kristjan Pomm,R. Ladva,Paul Korrovits,Maris Laan +7 more
TL;DR: Novel insights and improved clarity were achieved in the comprehensive analysis regarding the absolute, causative and plausible factors behind male infertility, as well as the ‘potential contributing factors’.
Journal ArticleDOI
Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios.
TL;DR: SDF testing is recommended in patients with clinical varicocele and borderline to normal semen parameters as it can better select varicocelectomy candidates and predict fertility and monitor the patient’s response to intervention.
Journal ArticleDOI
Smoking and Male Infertility: An Evidence-Based Review
Avi Harlev,Avi Harlev,Ashok Agarwal,Sezgin Gunes,Sezgin Gunes,Amit Shetty,Stefan S. du Plessis,Stefan S. du Plessis +7 more
TL;DR: This review sheds light upon the arguable association between smoking and male fertility and also assesses the impact of non-smoking routes of tobacco consumption on male infertility.
Journal ArticleDOI
Role of Oxidative Stress in Pathogenesis of Varicocele and Infertility
Ashok Agarwal,Rakesh Sharma,Nisarg R Desai,Sushil Prabakaran,Antonio Tavares,Edmund Sabanegh +5 more
TL;DR: It is concluded that spermatozoal dysfunction in varicocele patients could be multifactorial, and oxidative stress-induced injury appears to be one of the main causes.
References
More filters
Journal ArticleDOI
Gastrointestinal bleeding during low-dose aspirin administration for prevention of arterial occlusive events. A critical analysis.
TL;DR: The combination of the results showed that the occurrence of bleeding was 1.5 times higher in patients treated with low-dose aspirin in doses of 75-325 mg/day as compared with placebo.
Journal ArticleDOI
Varicocele size and results of varicocelectomy in selected subfertile men with varicocele.
Lawrence Dubin,Richard D. Amelar +1 more
Journal ArticleDOI
Loss of fertility in men with varicocele.
TL;DR: Men with varicocele was palpable in 35% (352/1,001) of men with primary infertility and 81% (79/98) men with secondary infertility.
Journal ArticleDOI
Controlled trial of high spermatic vein ligation for varicocele in infertile men
TL;DR: In this paper, a randomized, controlled trial of high spermatic vein ligation was carried out to determine whether high ligation is an effective treatment for infertile men with clinical varicocele.
Journal ArticleDOI
Varicocele: a progressive or static lesion?
TL;DR: It is concluded that a varicocele in some men is a progressive and not a static lesion resulting in the loss of previously established fertility.
Related Papers (5)
Varicocele and male infertility: Part II: Pathophysiology of varicoceles in male infertility
Varicocele size and results of varicocelectomy in selected subfertile men with varicocele.
Lawrence Dubin,Richard D. Amelar +1 more