Journal ArticleDOI
Role of Oxidative Stress in Pathogenesis of Varicocele and Infertility
Ashok Agarwal,Rakesh Sharma,Nisarg R Desai,Sushil Prabakaran,Antonio Tavares,Edmund Sabanegh +5 more
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TLDR
It is concluded that spermatozoal dysfunction in varicocele patients could be multifactorial, and oxidative stress-induced injury appears to be one of the main causes.About:
This article is published in Urology.The article was published on 2009-03-01. It has received 187 citations till now. The article focuses on the topics: Varicocele & Literature survey.read more
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The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis
Lynne Robinson,Ioannis D. Gallos,Sarah J. Conner,Madhurima Rajkhowa,David Miller,Sheena E.M. Lewis,Jackson Kirkman-Brown,Arri Coomarasamy +7 more
TL;DR: The use of methods which select sperm without DNA damage for use in assisted conception treatment may reduce the risk of miscarriage, indicating that assays detecting DNA damage could be considered in those suffering from recurrent pregnancy loss.
Journal ArticleDOI
The role of oxidative stress and antioxidants in male fertility.
TL;DR: It is shown in vitro and in vivo that studies demonstrate many antioxidants possess a beneficial effect on fertility and, therefore, their use is recommended as supportive therapy for the treatment of infertility in men.
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Whether sperm deoxyribonucleic acid fragmentation has an effect on pregnancy and miscarriage after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis
TL;DR: The results indicate that assays detecting sperm DNA damage should be recommended to those suffering from recurrent failure to achieve pregnancy, and selection of sperm without DNA damage for use may improve the clinical outcome of ART.
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The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review.
Konstantinos Michalakis,Gesthimani Mintziori,Athina Kaprara,Basil C. Tarlatzis,Dimitrios G. Goulis +4 more
TL;DR: An indirect evidence for the interplay between MS and reproductive axis is the fact that when treating components of one, parameters of the other can be improved as well, and therapeutic interventions include lifestyle modifications, pharmacological agents, such as sex hormone replacement therapy, and surgical procedures.
Journal ArticleDOI
Lifestyle factors in people seeking infertility treatment - A review.
TL;DR: This paper aims to clarify what preconception advice should be offered to people presenting for infertility treatment and why it is important to have this advice before deciding whether or not to have a child.
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Journal ArticleDOI
Clinical relevance of oxidative stress in male factor infertility: an update.
TL;DR: In this article, the authors discuss the need of ROS in normal sperm physiology, the mechanism of production of ROS and its pathophysiology in relation to male reproductive system and highlight the emerging concept of utilizing ROS as a method of contraception and the potential problems associated with it.
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Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A
Sho-ichi Yamagishi,Diane Edelstein,Xue Liang Du,Yasufumi Kaneda,Manuel Guzmán,Michael Brownlee +5 more
TL;DR: It is found that leptin increases ROS generation in BAEC in a dose-dependent manner and that its effects are additive with those of glucose, which may play an important role in the progression of atherosclerosis in insulin-resistant obese diabetic patients.
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Reduction of the Incidence of Sperm DNA Fragmentation by Oral Antioxidant Treatment
TL;DR: Data show that sperm DNA damage can be efficiently treated with oral antioxidants administered during a relatively short time period.
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The reactive oxygen species—total antioxidant capacity score is a new measure of oxidative stress to predict male infertility
TL;DR: ROS-TAC score is a novel measure of oxidative stress and is superior to ROS or TAC alone in discriminating between fertile and infertile men.
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Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation
TL;DR: Irrespective of the clinical diagnosis and semen characteristics, the presence of seminal oxidative stress in infertile men suggests its role in the pathophysiology of infertility.