Smoking and Male Infertility: An Evidence-Based Review
Avi Harlev,Avi Harlev,Ashok Agarwal,Sezgin Gunes,Sezgin Gunes,Amit Shetty,Stefan S. du Plessis,Stefan S. du Plessis +7 more
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TLDR
This review sheds light upon the arguable association between smoking and male fertility and also assesses the impact of non-smoking routes of tobacco consumption on male infertility.Abstract:
Many studies have reported that the contents of cigarette smoke negatively affect sperm parameters, seminal plasma, and various other fertility factors. Nevertheless, the actual effect of smoking on male fertility is not clear. The effect of smoking on semen parameters is based on the well-established biological finding that smoking increases the presence of reactive oxygen species, thereby resulting in oxidative stress (OS). OS has devastating effects on sperm parameters, such as viability and morphology, and impairs sperm function, hence reducing male fertility. However, not all studies have come to the same conclusions. This review sheds light upon the arguable association between smoking and male fertility and also assesses the impact of non-smoking routes of tobacco consumption on male infertility. It also highlights the evidence that links smoking with male infertility, including newly emerging genetic and epigenetic data, and discusses the clinical implications thereof.read more
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Journal ArticleDOI
Oxidative stress and male infertility
TL;DR: Lifestyle interventions including yoga and meditation can substantially improve the integrity of sperm DNA by reducing levels of oxidative DNA damage, regulating oxidative stress and by increasing the expression of genes responsible for DNA repair, cell-cycle control and anti-inflammatory effects.
Journal ArticleDOI
Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility
Ashok Agarwal,Neel Parekh,Manesh Kumar Panner Selvam,Ralf Henkel,Ralf Henkel,Rupin Shah,Sheryl T. Homa,Ranjith Ramasamy,Edmund Y. Ko,Kelton Tremellen,Sandro C. Esteves,Sandro C. Esteves,Ahmad Majzoub,Ahmad Majzoub,Juan G. Alvarez,David K. Gardner,Channa N. Jayasena,Channa N. Jayasena,Jonathan Ramsay,Chak-Lam Cho,Ramadan A Saleh,Denny Sakkas,James M. Hotaling,Scott Lundy,Sarah C. Vij,Joel L. Marmar,Jaime Gosálvez,Edmund Sabanegh,Hyun Jun Park,Armand Zini,Parviz Kavoussi,Sava Micic,Ryan P. Smith,Gian Maria Busetto,Mustafa Emre Bakircioglu,Gerhard Haidl,Giancarlo Balercia,Nicolás Garrido Puchalt,Moncef Ben-Khalifa,Nicholas N. Tadros,Jackson Kirkman-Browne,Sergey I. Moskovtsev,Xuefeng Huang,Edson Borges,Daniel R. Franken,Natan Bar-Chama,Yoshiharu Morimoto,Kazuhisa Tomita,Vasan Satya Srini,Willem Ombelet,Elisabetta Baldi,Monica Muratori,Yasushi Yumura,Sandro La Vignera,Raghavender Kosgi,Marlon Martinez,Donald P. Evenson,Daniel Suslik Zylbersztejn,Matheus Roque,Marcello Cocuzza,Marcelo Vieira,Assaf Ben-Meir,Raoul Orvieto,Raoul Orvieto,Eliahu Levitas,Amir Wiser,Amir Wiser,Mohamed Arafa,Vineet Malhotra,Sijo Parekattil,Haitham Elbardisi,Luiz Carvalho,Rima Dada,Christophe Sifer,Pankaj Talwar,Ahmet Gudeloglu,Ahmed M A Mahmoud,Khaled Terras,Chadi Yazbeck,Bojanic Nebojsa,Damayanthi Durairajanayagam,Ajina Mounir,Linda G. Kahn,Saradha Baskaran,Rishma Pai,Donatella Paoli,Kristian Leisegang,Mohamed Reza Moein,Sonia Malik,Önder Yaman,Luna Samanta,Fouad Bayane,Sunil Jindal,Muammer Kendirci,Barış Altay,Dragoljub Perovic,Avi Harlev +96 more
TL;DR: Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants) and may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose.
Journal ArticleDOI
Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management
TL;DR: Physiological ROS production, roles of genetic and epigenetic factors on the OS and male infertility with various mechanisms such as lipid peroxidation, DNA damage, and disorder of male hormone profile, inflammation, and varicocele are described.
Journal ArticleDOI
Role of oxidative stress, infection and inflammation in male infertility.
Ashok Agarwal,Mohit Rana,Emily Qiu,Hashem AlBunni,Albert D. Bui,Albert D. Bui,Ralf Henkel,Ralf Henkel +7 more
TL;DR: This review is focusing on infection and inflammation‐mediated OS, the inflammatory markers underlying pathology, clinical significance in male infertility, and a brief description of the recommended treatment modalities.
Journal ArticleDOI
Lifestyle causes of male infertility.
TL;DR: The major lifestyle factors discussed in the present review are amongst the multiple potential risk factors that could impair male fertility, however, their negative impact may well be mostly overcome by behaviour modification and better lifestyle choices.
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