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Elemental diets in treatment of acute Crohn's disease

C. Ó'moráin, +2 more
- 01 Nov 1980 - 
- Vol. 281, Iss: 6249, pp 1173-1175
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TLDR
Twenty-seven patients with 32 acute exacerbations of Crohn's disease were treated for four weeks with an elemental diet, and 29 of the exacerbations had remitted both clinically and biochemically.
Abstract
Twenty-seven patients with 32 acute exacerbations of Crohn's disease were treated for four weeks with an elemental diet. At the end of treatment 29 of the exacerbations had remitted both clinically and biochemically. After six months six patients had relapsed. These findings suggest that the elemental diet is effective in treating acute Crohn's disease, but the reasons are not clear. The diet may be effective because it provides nutritional support, is hypoallergenic, acts as a medical bypass from the affected area, or alters bowel flora. The patient's general wellbeing is improved by the supply of adequate energy and essential foodstuffs in a form easily available without further digestion and given in a safe, simple, non-toxic way.

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Journal ArticleDOI

Elemental diet as primary treatment of acute Crohn's disease: a controlled trial.

C. Ó'moráin, +2 more
- 23 Jun 1984 - 
TL;DR: Assessment at four and 12 weeks showed that the patients treated with the elemental diet had improved as much as and by some criteria more than the steroid treated group.
Journal ArticleDOI

Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression

TL;DR: Investigation of the possibility that the TNF-alpha-induced increase in intestinal epithelial TJ permeability was regulated by myosin light-chain kinase (MLCK) protein expression indicates for the first time that this mechanism was mediated by an increase in MLCK protein expression.
Journal ArticleDOI

Meta-analysis of enteral nutrition as a primary treatment of active crohn's disease

TL;DR: Comparing by meta-analysis the likelihood of clinical response to liquid diet therapy vs. corticosteroids and the importance of formula composition to efficacy, data analyzed do not support an advantage to elemental feedings compared with a polymeric formulation.
Journal ArticleDOI

Absorption of 151chromium-labeled ethylenediaminetetraacetate in inflammatory bowel disease

TL;DR: Intestinal permeability was assessed in patients with inflammatory bowel disease by measuring the urine excretion of 151 chromium-labeled ethylenediaminetetraacetate over periods up to 24 h after oral administration to appear to be a sensitive, noninvasive test for assessing small intestinal integrity.
Journal ArticleDOI

Chronic intermittent elemental diet improves growth failure in children with Crohn's disease

TL;DR: It is demonstrated that chronic intermittent elemental diet effectively reverses growth arrest, while decreasing prednisone requirements and Crohn's disease activity index in pediatric Crohn't disease patients prior to puberty.
References
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Journal ArticleDOI

Prediction of adult height from height, bone age, and occurrence of menarche, at ages 4 to 16 with allowance for midparent height.

TL;DR: Multiple regression equations for predicting the adult height of boys and girls from height and bone age at ages 4 and upwards are presented and it is shown that in clearly pathological children, such as those with endocrinopathies, they do not apply.
Journal ArticleDOI

Experience With Elemental Diet in the Treatment of Inflammatory Bowel Disease: Is This Primary Therapy?

TL;DR: Elementary diet is able to provide nutrition while allowing bowel rest, without the risks of intravenous hyperalimentation, and occasionally indications for surgery resolve during the period of nutritional improvement.
Journal ArticleDOI

Hyperalimentation as primary therapy for inflammatory bowel disease

TL;DR: The response in the group with regional enteritis and granulomatous colitis suggests the hyperalimentation may be of value as primary therapy, and total parenteral nutrition appears to be more of a supportive nature.
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These findings suggest that the elemental diet is effective in treating acute Crohn's disease, but the reasons are not clear.