Journal ArticleDOI
Endogenous corticoids and lung development in the fetal rabbit.
TLDR
In the rabbit, increases in plasma cortisol and nuclear receptor-cortisol complex are not temporally associated with the major events of lung development as in other species.Abstract:
Corticosteroid treatment of the fetus, which accelerates lung maturation, may mimic a modulating role of endogenous corticoids in normal development. To investigate this question, we determined the developmental pattern of plasma corticoids and their binding proteins in the rabbit, a commonly used species for studies of lung differentiation. The concentration of cortisol, the most potent glucocorticoid in the rabbit, was maximal at 23 days gestation (1.89 μg/dl), declining to 0.54 μg/dl at term (31 days). Levels of plasma corticosterone were always lower than those of cortisol. The adrenal content of corticoids, expressed per adrenal DNA or g BW, decreased during late gestation. Corticosteroid-binding globulin in fetal plasma decreased strikingly between day 23 (36 fig cortisol bound/dl) and day 31 (4.4 μg/dl; P < 0.001), whereas maternal levels increased about 10-fold during this time. Free cortisol in the fetus increased between 21 and 23 days (0.041 μg/dl) and then decreased somewhat until after day 29...read more
Citations
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Journal ArticleDOI
Effect of glucocorticoids on neonatal rabbit renal cortical sodium- inorganic phosphate messenger RNA and protein abundance
Satish Prabhu,Moshe Levi,Moshe Levi,Vangipuram Dwarakanath,Mazan Arar,Jürg Biber,Heini Murer,Michel Baum +7 more
TL;DR: There is a maturational decrease in NaPi-6 protein abundance and that glucocorticoids decrease neonatal phosphate transport, at least in part, by reducing the number of Na-Pi transporters.
Journal ArticleDOI
Inositol and glucocorticoid in the development of lung stability in male and female rabbit fetuses.
TL;DR: Inositol modifies the physiologic and biochemical response of the immature fetal lung to a pharmacologic dose of exogenous glucocorticoid to prevent the glucoc Corticoid-induced decrease in lung protein and, to a lesser extent, the decrease in DNA.
Book ChapterDOI
Glio-Neuronal Interactions in Retinal Development
Andreas Reichenbach,Angela Germer,Andreas Bringmann,Bernd Biedermann,Thomas Pannicke,Mike Francke,Heidrun Kuhrt,Winfried Reichelt,Andreas F. Mack +8 more
TL;DR: Muller cells have been found in the retinae of all vertebrates where they constitute the dominant type of macroglia and form elaborate sheaths around neuronal somata, dendrites and synapses, and fascicles of optic axons.
Journal ArticleDOI
Maturation of proximal tubular acidification.
Michel Baum,Raymond Quigley +1 more
TL;DR: The lower rate of neonatal PCT bicarbonate transport is due to lower activities of the apical Na+/H+ antiporter, apical H+-ATPase and basolateral Na(HCO3)3 symporter.
Journal ArticleDOI
Concentrations of serum cortisol, progesterone, estradiol-17β, cholesterol and cholesterol ester in the doe during the reproductive stadium, in the fetal serum, in the amniotic fluid and in the milk of rabbits, as well as correlations between these parameters
Klaus Kriesten,Uwe Murawski +1 more
TL;DR: Serum progesterone and estradiol-17β were significantly enhanced during gestation, while the content of cortisol showed a marked elevation at the end of pregnancy, and cholesterol and cholesterol ester concentrations markedly decreased after parturition and in the first week of lactation.
References
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