Journal ArticleDOI
Enhancement of stereospecific opiate binding to neural membranes by phosphatidyl serine
Leo G. Abood,Fumiyo Takeda +1 more
Reads0
Chats0
TLDR
It was established that sufficient exogenous lipid was associated with the membrane to account for the enhancement of opiate binding, and it was suggested that phosphatidyl serine may be an important component of the opiate pharmacophore.About:
This article is published in European Journal of Pharmacology.The article was published on 1976-09-01. It has received 50 citations till now. The article focuses on the topics: Lecithin & Membrane lipids.read more
Citations
More filters
Journal ArticleDOI
Interaction of drugs with calmodulin. Biochemical, pharmacological and clinical implications.
TL;DR: The fundamental role calmodulin plays in biology suggests that this calcium binding protein may provide a new site for the pharmacological manipulation of biological activity, and the inhibitors described hardly scratch the surface of this fertile area of research.
Journal ArticleDOI
A protein-lipid model of the opiate receptor
Nancy M. Lee,Andrew P. Smith +1 more
TL;DR: A model of the opiate-receptor is proposed which consists of both protein and lipid; the former contains a binding site for enkephalins, and the latter a site for alkaloids, with β-endorphin interacting with both sites.
Journal ArticleDOI
Role of phospholipids in muscarinic binding by neural membranes.
TL;DR: Ionic, pH and temperature effects on QNB binding indicate that the association of QNB with muscarinic receptors involves primarily hydrophobic interactions, with inhibition by low concentrations of cationic detergents completely reversible by PS and PA.
References
More filters
Journal ArticleDOI
Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation XXV. RECONSTITUTION OF VESICLES CATALYZING 32Pi—ADENOSINE TRIPHOSPHATE EXCHANGE
Yasuo Kagawa,Efraim Racker +1 more
TL;DR: It was shown that the reconstitution of vesicular structures with functional activity required several hours and that the formation of new vesicles from solubilized P-lipids was obtained by demonstrating inclusion of macromolecules such as 14C-labeled inulin or ferritin which could not be removed by washing.
Journal ArticleDOI
Properties of Opiate-Receptor Binding in Rat Brain
TL;DR: Potencies of opiates and their antagonists in displacing [(3)H]naloxone binding parallel their pharmacological potencies.
Journal ArticleDOI
Exchange of phospholipids between liver mitochondria and microsomes in vitro.
TL;DR: Liver mitochondria derived from rats injected with leucine-3H and with phosphate-32P or with glycerol-14C were incubated with nonlabeled microsomes in the presence of supernatant or of sucrose-EDTA to measure exchange of phospholipid.
Journal Article
Opiate receptor binding: effects of enzymatic treatments.
TL;DR: The opiate receptor appears to be a membrane-bound complex whose stereospecific binding is dependent upon the integrity of both proteins and phospholipids, suggesting the presence of more than one population of sites sensitive to proteolysis.