Journal ArticleDOI
Enzyme-catalyzed organic synthesis: practical routes to aza sugars and their analogs for use as glycoprocessing inhibitors
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This article is published in Accounts of Chemical Research.The article was published on 1993-04-01. It has received 261 citations till now. The article focuses on the topics: Organic synthesis.read more
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Recent Developments of Transition-State Analogue Glycosidase Inhibitors of Non-Natural Product Origin
Journal ArticleDOI
Recent Advances in the Chemoenzymatic Synthesis of Carbohydrates and Carbohydrate Mimetics.
Journal ArticleDOI
Synthesis of chiral pharmaceutical intermediates by biocatalysis
TL;DR: Chiral intermediates were prepared by biocatalytic processes for the chemical synthesis of four pharmaceutical drug candidates and served as intermediates for thromboxane A2 antagonist.
Journal ArticleDOI
Chemical Selection for Catalysis in Combinatorial Antibody Libraries
Kim D. Janda,Lee-Chiang Lo,Chih-Hung L. Lo,Mui Mui Sim,Ruo Wang,Chi-Huey Wong,Richard A. Lerner +6 more
TL;DR: A method that allows for the direct chemical selection for catalysis from antibody libraries was devised, whereby the positive aspects of hybridoma technology were preserved and re-formatted in the filamentous phage system to allow direct selection of catalysis.
References
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Book ChapterDOI
Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens
TL;DR: Aberrant glycosylation as such may be the basis of inappropriate cell/cell and cell/matrix interactions that may be reflected in the abnormal cell social behavior of tumor cells, such as uncontrolled cell growth, invasiveness, and metastatic potential.
Journal ArticleDOI
Inhibitors of the Biosynthesis and Processing of N-Linked Oligosaccharide Chains
TL;DR: A number of inhibitors have been identified that interfere with glycoprotein biosynthesis, processing, or transport, such as tunicamycin, tridecaptin, and flavomycin this paper.
Inhibitors of the biosynthesis and processing of n-linked
TL;DR: A number of glycoproteins have oligosaccharides linked to protein in a GlcNAc----asparagine bond that are either of the complex, the high-mannose or the hybrid structure and a number of inhibitors have been identified that interfere with glycoprotein biosynthesis, processing, or transport.
Journal ArticleDOI
A rule to predict which enantiomer of a secondary alcohol reacts faster in reactions catalyzed by cholesterol esterase, lipase from Pseudomonas cepacia, and lipase from Candida rugosa
Romas J. Kazlauskas,Romas J. Kazlauskas,Alexandra N. E. Weissfloch,Aviva Rappaport,Louis A. Cuccia +4 more