Journal ArticleDOI
Epidemiology of ciprofloxacin resistance among patients with methicillin-resistant Staphylococcus aureus
Sharon M. Smith,Robert H. K. Eng,Robert H. K. Eng,Pammi Bais,Patty Fan-Havard,Flor Tecson-Tumang +5 more
TLDR
During the first twelve months after ciprofloxacin was introduced for clinical use at this institution, 65 new patients were found to be either infected or colonized by methicillin-resistant Staphylococcus aureus (MRSA) which were also cIProfl oxacin resistant (CR-MRSA).Abstract:
During the first twelve months after ciprofloxacin was introduced for clinical use at our institution, 65 new patients were found to be either infected or colonized by methicillin-resistant Staphylococcus aureus (MRSA) which were also ciprofloxacin resistant (CR-MRSA). Only 18 of these patients (28%) had been previously exposed to this antibiotic. Nine (50%) of the 18 patients had received ciprofloxacin for treatment for a pathogen other than MRSA. Although the initial cases of colonization or infection with CR-MRSA can be directly related to ciprofloxacin use, many of the subsequent cases of colonization and infection were not the consequence of ciprofloxacin therapy but rather hospital transmission of existing CR-MRSA.read more
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Methicillin-Resistant Staphylococcus aureus in Europe
TL;DR: In order to obtain pan-European data on methicillin-resistantStaphylococcus aureus (MRSA), 43 laboratories from 10 European countries each screened 200 consecutive Staphyloccus Aureus isolates for MRSA resistance only one isolate per patient was permitted All participants used a uniform oxacillin-supplemented screening plate and sent to Munich for reconfirmation and further susceptibility testing as mentioned in this paper.
Journal ArticleDOI
Methicillin-resistant Staphylococcus aureus: A consensus review of the microbiology, pathogenesis, and epidemiology with implications for prevention and management
Maury Ellis Mulligan,Katherine A. Murray-Leisure,Bruce S. Ribner,Harold C. Standiford,Joseph F. John,Joyce A. Korvick,Carol A. Kauffman,Victor L. Yu +7 more
TL;DR: Indications for antibiotic therapy for eradication of colonization and treatment of infection are reviewed, and recommendations for handling an outbreak, surveillance, and culturing of patients are presented based on the known epidemiology.
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Emerging fluoroquinolone resistance in bacterial keratitis: A 5-year review
TL;DR: This in vitro study shows a significant increased resistance of S. aureus to the fluoroquinolones from 1993 to 1997, which raises concern for the use of monotherapy in treating bacterial keratitis.
Journal ArticleDOI
Ciprofloxacin. An updated review of its pharmacology, therapeutic efficacy and tolerability.
TL;DR: Ciprofloxacin has retained its excellent activity against most Gram-negative bacteria, and fulfilled its potential as an important antibacterial drug in the treatment of a wide range of infections.
Journal ArticleDOI
Fluoroquinolone resistance among Gram-positive cocci.
TL;DR: In this article, the authors highlighted the importance of careful use of these agents in appropriate patients and doses, as well as careful infection-control practices, and emphasized the utility of a valuable class of antimicrobial agents.