Esophageal carcinoma advances in treatment results for locally advanced disease: review
TLDR
Chemo (PF) before surgery improved overall survival (OS) in those patients in most of the randomized trials and in meta-analyses and it was found that those patients with pathologic complete response to the initial treatment did better than those who had no improvement at all.About:
This article is published in Annals of Oncology.The article was published on 2012-05-01 and is currently open access. It has received 96 citations till now. The article focuses on the topics: Chemoradiotherapy & Combined Modality Therapy.read more
Citations
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Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Hong Yang,Hui Liu,Yuping Chen,Chengchu Zhu,Wentao Fang,Zhentao Yu,Weimin Mao,Jiaqing Xiang,Yongtao Han,Zhijian Chen,Haihua Yang,Jiaming Wang,Qingsong Pang,Xiao Zheng,Huanjun Yang,Tao Li,Florian Lordick,Xavier B. D’Journo,Robert J. Cerfolio,Robert J. Korst,Nuria M. Novoa,Scott J. Swanson,Alessandro Brunelli,Mahmoud Ismail,Hiran C. Fernando,Xu Zhang,Qun Li,Geng Wang,Baofu Chen,Teng Mao,Min Kong,Xufeng Guo,Ting Lin,Mengzhong Liu,Jianhua Fu +34 more
TL;DR: This trial shows that NCRT plus surgery improves survival over surgery alone among patients with locally advanced ESCC, with acceptable and manageable adverse events.
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Towards predicting the response of a solid tumour to chemotherapy and radiotherapy treatments: clinical insights from a computational model.
TL;DR: A hybrid multiscale mathematical model is used that incorporates both individual cell behaviour through the cell-cycle and the effects of the changing microenvironment through oxygen dynamics to study the multiple effects of radiation therapy.
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MMP1 promotes tumor growth and metastasis in esophageal squamous cell carcinoma
TL;DR: The data suggest that MMP1 functions as an oncogene and serves as a prognostic biomarker and a potential therapeutic target in ESCC.
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Outcome of patients with esophageal cancer: a nationwide analysis.
Miao-Fen Chen,Yao-Hsu Yang,Yao-Hsu Yang,Chia-Hsuan Lai,Pau-Chung Chen,Wen-Cheng Chen,Wen-Cheng Chen +6 more
TL;DR: The data indicated that age, sex, and curative treatment were significant predictors of lifetime survival in patients with esophageal cancer, andCurative treatment with surgery improved the survival of esophagal cancer patients more significantly compared with patients who undergo definite radiotherapy.
Journal ArticleDOI
Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma: The NEOCRTEC5010 Randomized Clinical Trial.
Hong Yang,Hui Liu,Yuping Chen,Chengchu Zhu,Wentao Fang,Zhentao Yu,Zhentao Yu,Weimin Mao,Jiaqing Xiang,Yongtao Han,Zhijian Chen,Zhijian Chen,Haihua Yang,Jiaming Wang,Qingsong Pang,Xiao Zheng,H. Yang,Tao Li,Xu Zhang,Qun Li,Geng Wang,Baofu Chen,Teng Mao,Min Kong,Xufeng Guo,Ting Lin,Mengzhong Liu,Jianhua Fu +27 more
TL;DR: In this article, the authors compared the treatment efficacy of NCRT plus surgery with surgery alone for long-term survival among patients with locally advanced esophageal squamous cell carcinoma (ESCC).
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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Perioperative Chemotherapy versus Surgery Alone for Resectable Gastroesophageal Cancer
David Cunningham,William H. Allum,Sally P. Stenning,Jeremy Thompson,Marianne Nicolson,J. Howard Scarffe,F. Lofts,Stephen Falk,Timothy Iveson,David Smith,Ruth E Langley,Monica Verma,Simon Weeden,Yu Jo Chua +13 more
TL;DR: In patients with operable gastric or lower esophageal adenocarcinomas, a perioperative regimen of ECF decreased tumor size and stage and significantly improved progression-free and overall survival.
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Changing patterns in the incidence of esophageal and gastric carcinoma in the United States
TL;DR: The authors update the incidence trends through 1994 and further consider the trends by age group.
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A comparison of multimodal therapy and surgery for esophageal adenocarcinoma.
TL;DR: Multimodal treatment is superior to surgery alone for patients with resectable adenocarcinoma of the esophagus, with the survival advantage favoring multimodal therapy reaching significance at three years.
Journal ArticleDOI
Combined Chemotherapy and Radiotherapy Compared with Radiotherapy Alone in Patients with Cancer of the Esophagus
Arnold Herskovic,Karen L. Martz,Muhyi Al-Sarraf,Lawrence Leichman,Jeffrey Brindle,Vainutis K. Vaitkevicius,Jay S. Cooper,Roger W. Byhardt,Lawrence C. Davis,Bahman Emami +9 more
TL;DR: In this article, a phase III prospective, randomized, and stratified trial was undertaken to evaluate the efficacy of four courses of combined fluorouracil (1000 mg per square meter of body-surface area daily for four days) and cisplatin (75 mg persquare meter on the first day) plus 5000 cGy of radiation therapy, as compared with 6400 cGyof radiation therapy alone, in patients with squamous-cell carcinoma or adenocarcinoma of the thoracic esophagus.
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