Evaluation of histological scoring systems for tissue-engineered, repaired and osteoarthritic cartilage
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TLDR
A great variety of histological scoring systems exists for analysis of osteoarthritic or normal, in vivo repaired or tissue-engineered cartilage, but only few have been validated.About:
This article is published in Osteoarthritis and Cartilage.The article was published on 2010-01-01 and is currently open access. It has received 188 citations till now. The article focuses on the topics: Hyaline cartilage & Cartilage.read more
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Animal models of osteoarthritis: classification, update, and measurement of outcomes.
TL;DR: This review summarizes the current understanding of the disease pathogenesis, invasive and non-invasive animal models, imaging modalities, and pain assessment techniques in the animals.
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Animal Models of Osteoarthritis Comparisons and Key Considerations
TL;DR: This review provides general considerations for model selection, as well as important features of species such as mouse, rat, guinea pig, sheep, goat, and horse, which researchers should be mindful of when choosing the “best” animal model for their intended purpose.
Journal ArticleDOI
Sport injuries: a review of outcomes.
TL;DR: An updated synthesis of existing clinical evidence of long-term follow-up outcome of sports injuries is provided, allowing more accurate assessment of hip, ankle, shoulder, elbow and wrist intra-articular post-traumatic pathologies, and possibly more successful management.
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In situ handheld three‐dimensional bioprinting for cartilage regeneration
Claudia Di Bella,Claudia Di Bella,Serena Duchi,Cathal D O'Connell,Romane Blanchard,Cheryl Augustine,Zhilian Yue,Fletcher William Thompson,Christopher J. Richards,Stephen Beirne,Carmine Onofrillo,Carmine Onofrillo,Sébastien H Bauquier,Stewart D. Ryan,Peter Pivonka,Gordon G. Wallace,Peter F. M. Choong,Peter F. M. Choong +17 more
TL;DR: The results of this study show that real‐time, in vivo bioprinting with cells and scaffold is a feasible means of delivering a regenerative medicine strategy in a large animal model to regenerate articular cartilage.
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Mussel-Inspired Tissue-Adhesive Hydrogel Based on the Polydopamine–Chondroitin Sulfate Complex for Growth-Factor-Free Cartilage Regeneration
Lu Han,Menghao Wang,Pengfei Li,Donglin Gan,Liwei Yan,Jielong Xu,Kefeng Wang,Liming Fang,Chun Wai Chan,Hongping Zhang,Huipin Yuan,Xiong Lu +11 more
TL;DR: This tissue-adhesive and tough PDA-CS-PAM hydrogel with good cell affinity creates a growth-Factor-free and biomimetic microenvironment for chondrocyte growth and cartilage regeneration and sheds light on the development of growth-factor-free biomaterials for cartilage repair.
References
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Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
TL;DR: Cultured autologous chondrocytes can be used to repair deep cartilage defects in the femorotibial articular surface of the knee joint.
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The validation of visual analogue scales as ratio scale measures for chronic and experimental pain
TL;DR: Visual analogue scales (VAS) of sensory intensity and affective magnitude were validated as ratio scale measures for both chronic and experimental pain, demonstrating the valid use of VAS for the measurement of and comparison between chronic pain and experimental heat pain.
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Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data.
TL;DR: For thirty-two areas of cartilage from nine osteo-arthritic and four "normal" femoral heads a histologic-histochemical grade was assigned as an index of severity of the osteo -arthritic process.
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Osteoarthritis cartilage histopathology: grading and staging
Kenneth P.H. Pritzker,Kenneth P.H. Pritzker,Sergio A. Jimenez,Keld Ostergaard,J.-P. Pelletier,P A Revell,Donald Salter,W.B. van den Berg +7 more
TL;DR: The OARSI cartilage OA histopathology grading system appears consistent and simple to apply as discussed by the authors, however, further studies are required to confirm the system's utility, as well as their reproducibility and validity.
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Mesenchymal Cell-Based Repair of Large Full Thickness Defects of Articular Cartilage
Shigeyuki Wakitani,Tatsuhiko Goto,S. Pineda,Randell G. Young,Joseph M. Mansour,Arnold I. Caplan,Victor M. Goldberg +6 more
TL;DR: Osteochondral progenitor cells were used to repair large, full-thickness defects of the articular cartilage that had been created in the knees of rabbits.