Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.
TLDR
The existence of many new and encouraging biological approaches to cartilage repair justifies the future investment of time and money in this research area, particularly given the extremely high socio-economic importance of such therapeutic strategies in the prevention and treatment of these common joint diseases and traumas.About:
This article is published in Osteoarthritis and Cartilage.The article was published on 2002-06-01 and is currently open access. It has received 1868 citations till now. The article focuses on the topics: Articular cartilage repair.read more
Citations
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Bioactive glass in tissue engineering
Mohamed N. Rahaman,Delbert E. Day,B. Sonny Bal,Qiang Fu,Steven B. Jung,Lynda F. Bonewald,Antoni P. Tomsia +6 more
TL;DR: Recent work has shown the ability of bioactive glass to promote angiogenesis, which is critical to numerous applications in tissue regeneration, such as neovascularization for bone regeneration and the healing of soft tissue wounds.
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Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial.
Gunnar Knutsen,Lars Engebretsen,Tom C. Ludvigsen,Jon Olav Drogset,Torbjørn Grøntvedt,Eirik Solheim,Torbjørn Strand,Sally Roberts,Vidar Isaksen,Oddmund Johansen +9 more
TL;DR: There was no significant difference in macroscopic or histological results between the two treatment groups and no association between the histological findings and the clinical outcome at the two-year time-point.
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Bacterial cellulose as a potential scaffold for tissue engineering of cartilage
Anna Svensson,Elin Nicklasson,Elin Nicklasson,Tim Harrah,Bruce Panilaitis,David L. Kaplan,Mats Brittberg,Paul Gatenholm +7 more
TL;DR: The results indicate that unmodified BC supports chondrocyte proliferation at levels of approximately 50% of the collagen type II substrate while providing significant advantages in terms of mechanical properties, and suggest the potential for this biomaterial as a scaffold for tissue engineering of cartilage.
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Nutrition of the intervertebral disc.
TL;DR: Loss of nutrient supply can lead to cell death, loss of matrix production, and increase in matrix degradation and hence to disc degeneration.
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Stem cell-based tissue engineering with silk biomaterials.
TL;DR: Stem cell-based tissue engineering using 3D silk fibroin scaffolds has expanded the use of silk-based biomaterials as promising scaffolds for engineering a range of skeletal tissues like bone, ligament, and cartilage, as well as connective tissues like skin.
References
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Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
TL;DR: Cultured autologous chondrocytes can be used to repair deep cartilage defects in the femorotibial articular surface of the knee joint.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
TL;DR: Marrow stromal cells present an intriguing model for examining the differentiation of stem cells and have several characteristics that make them potentially useful for cell and gene therapy.
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The efficiency of systematic sampling in stereology and its prediction
TL;DR: A set of very simple estimators of efficiency are presented and illustrated with a variety of biological examples and a nomogram for predicting the necessary number of points when performing point counting is provided.