Evidence for two types of brown adipose tissue in humans
Martin E. Lidell,Matthias J. Betz,Matthias J. Betz,Olof Dahlqvist Leinhard,Mikael Heglind,Louise Elander,Marc Slawik,Thomas Mussack,Daniel Nilsson,Thobias Romu,Pirjo Nuutila,Kirsi A. Virtanen,Felix Beuschlein,Anders Persson,Magnus Borga,Sven Enerbäck +15 more
TLDR
It is concluded that infants, similarly to rodents, have the bona fide iBAT thermogenic organ consisting of classical brown adipocytes that is essential for the survival of small mammals in a cold environment.Abstract:
The previously observed supraclavicular depot of brown adipose tissue (BAT) in adult humans was commonly believed to be the equivalent of the interscapular thermogenic organ of small mammals. This view was recently disputed on the basis of the demonstration that this depot consists of beige (also called brite) brown adipocytes, a newly identified type of brown adipocyte that is distinct from the classical brown adipocytes that make up the interscapular thermogenic organs of other mammals. A combination of high-resolution imaging techniques and histological and biochemical analyses showed evidence for an anatomically distinguishable interscapular BAT (iBAT) depot in human infants that consists of classical brown adipocytes, a cell type that has so far not been shown to exist in humans. On the basis of these findings, we conclude that infants, similarly to rodents, have the bona fide iBAT thermogenic organ consisting of classical brown adipocytes that is essential for the survival of small mammals in a cold environment.read more
Citations
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Brown and beige fat: development, function and therapeutic potential
Matthew J. Harms,Patrick Seale +1 more
TL;DR: Many genes and pathways that regulate brown and beige adipocyte biology have now been identified, providing a variety of promising therapeutic targets for metabolic disease.
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What We Talk About When We Talk About Fat
TL;DR: New perspective is gained on the roles played by adipocyte in a variety of homeostatic processes and on the mechanisms used by adipocytes to communicate with other tissues and how these relationships are altered during metabolic disease and how they might be manipulated to restore metabolic health.
Journal Article
Medical Image Computing and Computer-Assisted Intervention
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Adipose tissue browning and metabolic health
Alexander Bartelt,Joerg Heeren +1 more
TL;DR: Stimulating the development of beige adipocytes in WAT (so called 'browning') might reduce adverse effects of WAT and could help to improve metabolic health, as well as inspire new avenues to increase the capacity for adaptive thermogenesis.
Journal ArticleDOI
Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist
Aaron M. Cypess,Lauren S Weiner,Carla Roberts-Toler,Elisa F. Elia,Skyler H. Kessler,Peter A. Kahn,Jeffrey English,Kelly Chatman,Sunia A. Trauger,Alessandro Doria,Gerald M. Kolodny +10 more
TL;DR: A β3-AR agonist can stimulate human BAT thermogenesis and may be a promising treatment for metabolic disease.
References
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Journal ArticleDOI
Identification and Importance of Brown Adipose Tissue in Adult Humans
AM Cypess,Sanaz Lehman,Gethin Williams,Ilan Tal,Dean Rodman,Allison B. Goldfine,FC Kuo,Edwin L. Palmer,Yu-Hua Tseng,Alessandro Doria,Gerald M. Kolodny,C R Kahn +11 more
TL;DR: Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT.
Journal ArticleDOI
Cold-activated brown adipose tissue in healthy men.
Wouter D. van Marken Lichtenbelt,Joost W. Vanhommerig,Nanda M Smulders,Jamie Drossaerts,Gerrit J. Kemerink,Nicole D. Bouvy,Patrick Schrauwen,G J Jaap Teule +7 more
TL;DR: Brown adipose tissue may be metabolically important in men, and the fact that it is reduced yet present in most overweight or obese subjects may make it a target for the treatment of obesity.
Journal ArticleDOI
Functional brown adipose tissue in healthy adults.
Kirsi A. Virtanen,Martin E. Lidell,Janne Orava,Mikael Heglind,Rickard Westergren,Tarja Niemi,Markku Taittonen,Jukka Laine,Nina-Johanna Savisto,Sven Enerbäck,Pirjo Nuutila +10 more
TL;DR: These findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.
Journal ArticleDOI
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Jun Wu,Pontus Boström,Lauren M. Sparks,Li Ye,Jang Hyun Choi,An Hoa Giang,Melin J. Khandekar,Kirsi A. Virtanen,Pirjo Nuutila,Gert Schaart,Kexin Huang,Hua Tu,Wouter D. van Marken Lichtenbelt,Joris Hoeks,Sven Enerbäck,Patrick Schrauwen,Bruce M. Spiegelman +16 more
TL;DR: Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin, providing evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes.
Journal ArticleDOI
PRDM16 controls a brown fat/skeletal muscle switch
Patrick Seale,Bryan C. Bjork,Wenli Yang,Shingo Kajimura,Sherry Chin,Shihuan Kuang,Anthony Scimè,Srikripa Devarakonda,Heather M. Conroe,Hediye Erdjument-Bromage,Paul Tempst,Michael A. Rudnicki,David R. Beier,Bruce M. Spiegelman +13 more
TL;DR: It is shown by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage.