Brown and beige fat: development, function and therapeutic potential
Matthew J. Harms,Patrick Seale +1 more
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TLDR
Many genes and pathways that regulate brown and beige adipocyte biology have now been identified, providing a variety of promising therapeutic targets for metabolic disease.Abstract:
Adipose tissue, best known for its role in fat storage, can also suppress weight gain and metabolic disease through the action of specialized, heat-producing adipocytes. Brown adipocytes are located in dedicated depots and express constitutively high levels of thermogenic genes, whereas inducible 'brown-like' adipocytes, also known as beige cells, develop in white fat in response to various activators. The activities of brown and beige fat cells reduce metabolic disease, including obesity, in mice and correlate with leanness in humans. Many genes and pathways that regulate brown and beige adipocyte biology have now been identified, providing a variety of promising therapeutic targets for metabolic disease.read more
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Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
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References
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Journal ArticleDOI
Brown Adipose Tissue: Function and Physiological Significance
Barbara Cannon,Jan Nedergaard +1 more
TL;DR: The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
Journal ArticleDOI
Heart Disease and Stroke Statistics—2007 Update A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Wayne D. Rosamond,Katherine M. Flegal,Gary Friday,Karen L. Furie,Alan S. Go,Kurt J. Greenlund,Nancy Haase,Michael Ho,Virginia J. Howard,Bret Kissela,Steven J. Kittner,Donald M. Lloyd-Jones,Mary M. McDermott,James B. Meigs,Claudia S. Moy,Graham Nichol,Christopher J. O'Donnell,Véronique L. Roger,John S. Rumsfeld,Paul D. Sorlie,Julia Steinberger,Thomas Thom,Sylvia Wasserthiel-Smoller,Yuling Hong +23 more
TL;DR: This chapter describes the most important sources and the types of data the AHA uses from them and other government agencies to derive the annual statistics in this Update.
Journal ArticleDOI
Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.
Donald M. Lloyd-Jones,Robert J. Adams,Mercedes R. Carnethon,Giovanni de Simone,T. Bruce Ferguson,Katherine M. Flegal,Earl S. Ford,Karen L. Furie,Alan S. Go,Kurt J. Greenlund,Nancy Haase,Susan M. Hailpern,Michael Ho,Virginia J. Howard,Brett M. Kissela,Steven J. Kittner,Daniel T. Lackland,Lynda D. Lisabeth,Ariane Marelli,Mary M. McDermott,James B. Meigs,Dariush Mozaffarian,Graham Nichol,Christopther O'Donnell,Véronique L. Roger,Wayne D. Rosamond,Ralph L. Sacco,Paul D. Sorlie,Randall S. Stafford,Julia Steinberger,Thomas Thorn,Sylvia Wasserthiel-Smoller,Nathan D. Wong,Judith Wylie-Rosett,Yuling Hong +34 more
TL;DR: The statistical update brings together the most up-to-date statistics on heart disease, stroke, other vascular diseases, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update.
Journal ArticleDOI
Identification and Importance of Brown Adipose Tissue in Adult Humans
AM Cypess,Sanaz Lehman,Gethin Williams,Ilan Tal,Dean Rodman,Allison B. Goldfine,FC Kuo,Edwin L. Palmer,Yu-Hua Tseng,Alessandro Doria,Gerald M. Kolodny,C R Kahn +11 more
TL;DR: Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT.
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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Pere Puigserver,Zhidan Wu,Cheol Won Park,Reed A. Graves,Margaret E. Wright,Bruce M. Spiegelman +5 more
TL;DR: Results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis.