Open AccessJournal Article
Evidence that the effectiveness of antioxidants as inhibitors of 7,12-dimethylbenz(a) anthracene-induced mammary tumors is a function of dietary fat composition.
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TLDR
A study of tumor incidence and tumor growth rates in 7,12-dimethylbenz(a)anthracene-treated female Sprague-Dawley rats fed different types and amounts of dietary fat indicates that the difference in tumor incidence may be a reflection of marked differences in the growth of neoplastic clones to a palpable size within the time frame of the study.Abstract:
A study of tumor incidence and tumor growth rates in 7,12-dimethylbenz( a )anthracene-treated female Sprague-Dawley rats fed different types and amounts of dietary fat indicates that the difference in tumor incidence may be a reflection of marked differences in the growth of neoplastic clones to a palpable size within the time frame of the study. In addition, the observation is made that some antioxidants which inhibit tumor development in animals fed commercial rations are not effective when given in purified diets.read more
Citations
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Book ChapterDOI
Toxicological Aspects of Antioxidants Used as Food Additives
TL;DR: Not only did the new findings conflict with the results of earlier, negative, long-term studies, but also their significance for hazard assessment in man was surrounded by even more uncertainties than those which toxicologists are used to considering when extrapolating from animal experiments to man.
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Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats.
TL;DR: In this article, a comparison of the effects of a polyunsaturated vegetable oil (corn oil) containing linoleate with a fish oil (menhaden oil) derived from linolenic acid showed that higher dietary levels of corn oil increased the yield of DMBA-induced mammary tumors.
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Synthetic antioxidants: biochemical actions and interference with radiation, toxic compounds, chemical mutagens and chemical carcinogens
TL;DR: Current information is insufficient to promote expectations as to the use of antioxidants in the prevention of human cancer, and it is concluded that current information about antioxidant properties is insufficient.
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Vitamin E and cancer prevention.
Paul Knekt,Arpo Aromaa,J. Maatela,Ritva-Kaarina Aaran,Tapio Nikkari,Matti Hakama,Timo Hakulinen,Richard Peto,Lyly Teppo +8 more
TL;DR: The hypothesis that dietary vitamin E in some circumstances protects against cancer is confirmed, and the association was strongest among nonsmoking men and among women with low levels of serum selenium.
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Effect of Diets Containing Different Levels of Linoleic Acid on Human Breast Cancer Growth and Lung Metastasis in Nude Mice
TL;DR: Three different levels of dietary linoleic acid intake were determined on the growth of MDA-MB-435 human breast cancer cells in the mammary fat pads of nude mice, and their metastasis to the lungs, and the incidence of grossly visible pulmonary metastatic nodules was higher for both groups compared with the 2% LA-fed group.
References
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Journal ArticleDOI
Inhibition of chemical carcinogenesis.
TL;DR: Information will be presented concerning many compounds that have the capacity to inhibit the neoplastic effects of chemieal careinogens when administered either prior to exposure to the carcinogen or at the same time, Overall, this inhibition entails prevention of the active form of the carcinogens from reaching or reacting with the target site.
Journal Article
Effects of Dietary Fat on Mammary Carcinogenesis by 7,12-Dimethylbenz(α)anthracene in Rats
TL;DR: In this article, a semisynthetic high-corn oil diet enhanced the development of mammary cancer induced by 7,12-dimethylbenz(α)anthracene (DMBA) in intact female Sprague-Dawley rats.
Journal ArticleDOI
Incidence and Growth of Mammary Tumors Induced by 7, 12-Dimethylbenz[a]anthracene as Related to the Dietary Content of Fat and Antioxidant
Journal ArticleDOI
High dietary fat, elevation of rat serum prolactin and mammary cancer.
TL;DR: Direct evidence is submitted, based on the radioimmunoassay of serum prolactin, that animals maintained on high-fat diets (HF) exhibit significantly higher serum Prolactin levels during the proestrus-estrus period than animals fed low fat diets (LF).
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