Journal ArticleDOI
Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats.
TLDR
In this article, a comparison of the effects of a polyunsaturated vegetable oil (corn oil) containing linoleate with a fish oil (menhaden oil) derived from linolenic acid showed that higher dietary levels of corn oil increased the yield of DMBA-induced mammary tumors.Abstract:
High fat diets promote the development of mammary tumors induced in rats by 7,12-dimethylbenz(a)anthracene (DMBA), and polyunsaturated fats are more effective than saturated fats. This difference is related to the linoleic acid content of polyunsaturated vegetable oils, but the amount of linoleate required for maximum tumor promotion appears to be higher than indicated by earlier experiments. Comparison of the effects of a polyunsaturated vegetable oil (corn oil) containing linoleate with a fish oil (menhaden oil) containing polyunsaturated fatty acids derived from linolenic acid showed that higher dietary levels of corn oil increased the yield of DMBA-induced mammary tumors, while corresponding levels of menhaden oil had an inhibitory effect. This is further evidence that promotion of mammary tumorigenesis by polyunsaturated vegetable oils may be mediated by prostaglandins or other biologically active eicosanoids derived from n-6 fatty acids.read more
Citations
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Journal ArticleDOI
Omega-3 fatty acids as cancer chemopreventive agents.
David P. Rose,Jeanne M. Connolly +1 more
TL;DR: Several of the known risk factors for breast, and colon cancer may be favorably modified by dietary omega-3 FA supplementation, and the implementation of clinical chemoprevention trials is now feasible.
Journal ArticleDOI
Heterotrophic production of eicosapentaenoic acid by microalgae.
Zhiyou Wen,Feng Chen +1 more
TL;DR: This paper reviews recent advances in heterotrophic production of EPA by microalgae with an emphasis on the use of diatoms as producing organisms.
Journal ArticleDOI
Growth of and omega-3 fatty acid production by Phaeodactylum tricornutum under different culture conditions.
W Yongmanitchai,Owen P. Ward +1 more
TL;DR: While vitamins B1 and B12 did not affect growth significantly, EPA yield was increased by 65% by B12 supplementation, and the EPA content of total fatty acids increased with increasing concentrations of nitrate and urea.
Journal ArticleDOI
Multi-targeted therapy of cancer by omega-3 fatty acids.
TL;DR: The rationale for using long-chain n-3 PUFAs in cancer prevention and treatment and the challenges that such approaches pose in the design of clinical trials are discussed.
Journal ArticleDOI
Are all n-3 polyunsaturated fatty acids created equal?
TL;DR: A better understanding of the individual role for ALA, EPA and DHA is needed in order to make appropriate dietary recommendations regarding n-3 polyunsaturated fatty acid consumption, and potential mechanisms of action are reviewed.
References
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Journal ArticleDOI
Effect of Omega-3 Fatty Acids on Growth of a Rat Mammary Tumor
TL;DR: The mechanism underlying inhibition of mammary tumorigenesis may be linked, in part, to the inhibitory effect of both EPA and DHA on arachidonic acid metabolism.
Journal Article
Requirement of Essential Fatty Acid for Mammary Tumorigenesis in the Rat
TL;DR: The differences in tumor yield could not be correlated with changes in prostaglandin E concentration in the mammary fat pads of normal animals maintained on similar diets, suggesting that linoleate may act by some other mechanism to stimulate mammary tumorigenesis.
Journal ArticleDOI
Effects of level and type of dietary fat on incidence of mammary tumors induced in female sprague-dawley rats by 7,12-dimethylbenz(α) anthracene
Kenneth K. Carroll,H. T. Khor +1 more
TL;DR: Experiments indicated that unsaturated fats enhance the yield of adenocarcinomas more than saturated fats, and the possible relevance of these findings to the incidence of breast cancer in humans is discussed.
Journal Article
Effect of the prostaglandin synthetase inhibitor indomethacin on 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats fed different levels of fat.
TL;DR: Data suggest that at least part of the stimulatory effect of polyunsaturated fat on 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis may be mediated through an increased synthesis of prostaglandins.
Journal Article
Effect of Dietary Polyunsaturated Fatty Acids on Growth of Mammary Adenocarcinomas in Mice and Rats
Lewis A. Hillyard,S. Abraham +1 more
TL;DR: The results suggest that the growth-enhancing effect of dietary fat on transplantable mammary tumors may be mediated through the cellular immune system with the possible involvement of prostaglandins in this process.