Experimentally induced corticosteroid arthropathy
TLDR
The correlation between certain pre-existing patterns of cartilage histology and susceptibility to degenerative change may provide a clue to the localization of degenerative joint disease in humans.Abstract:
Intraarticular injections of triamcinolone acetonide resulted in deleterious changes in living rabbit articular knee cartilage. These changes were characterized by an increased frequency of chondrocyte nuclear degeneration and prominent cyst formation as compared with control animals. Degenerative changes were localized to the cartilage of the medial tibial plateau. This localization may be related to the different histologic pattern seen in this cartilage surface as compared to other areas of the knee. The correlation between certain pre-existing patterns of cartilage histology and susceptibility to degenerative change may provide a clue to the localization of degenerative joint disease in humans.read more
Citations
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Journal ArticleDOI
Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial.
Timothy E. McAlindon,Michael P. LaValley,William F. Harvey,Lori Lyn Price,Jeffrey B. Driban,Ming Zhang,Robert Ward +6 more
TL;DR: 2 years of intra-articular triamcinolone, compared with intra-artsicular saline, resulted in significantly greater cartilage volume loss and no significant difference in knee pain, and these findings do not support this treatment for patients with symptomatic knee osteoarthritis.
Journal ArticleDOI
The Reaction of Articular Cartilage to Injury and Osteoarthritis
TL;DR: Alterations in Cartilage in Osteoarthritis The morphologic changes in joints affected by osteoarth arthritis were identified in writings of the Hunter brothers over 200 years ago.
Journal ArticleDOI
The reaction of articular cartilage to injury and osteoarthritis (second of two parts).
Journal ArticleDOI
Experimentally induced degenerative joint lesions following partial meniscectomy in the rabbit.
Roland W. Moskowitz,Wirt Davis,James Sammarco,Mark Martens,Jack Baker,Michael Mayor,Albert H. Burstein,Victor H. Frankel +7 more
TL;DR: Degenerative lesions characterized by osteochondrophyte spur formation and cartilage degeneration were induced by partial meniscectomy in the rabbit knee and may be useful in studies of osteoarthritis pathogenesis, pathology and treatment.
Journal ArticleDOI
Intra-articular triamcinolone hexacetonide in knee osteoarthritis: factors influencing the clinical response.
TL;DR: THA provided short term pain relief in knee OA and increased benefit was associated with both clinical evidence of joint effusion and successful aspiration of synovial fluid at the time of injection.
References
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Journal Article
Hydrocortisone arthropathy--an experimental investigation
R. B. Salter,A. Gross,J. H. Hall +2 more
Journal ArticleDOI
Charcot-like Arthropathy Following Intra-Articular Hydrocortisone
TL;DR: Pathology obtained during a compression arthrodesis procedure showed changes comparable to that of a Charcot-like joint, and the possible relationship of such a change to the repeated injections of steroids is discussed.
Journal Article
Fine structure of articular cartilage in mice receiving cortisone acetate.
Journal Article
Mitosis of Chondrocytes Induced in the Knee Joint Articular Cartilage of Adult Rabbits
E. S. Crelin,W. O. Southwick +1 more
TL;DR: In this paper, the authors propose a method to solve the problem of unstructured data.Fig. 1 : Fig. 2 : Figure 1 : Unstructured Data Table.
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