Intra-articular triamcinolone hexacetonide in knee osteoarthritis: factors influencing the clinical response.
TLDR
THA provided short term pain relief in knee OA and increased benefit was associated with both clinical evidence of joint effusion and successful aspiration of synovial fluid at the time of injection.Abstract:
OBJECTIVE--To assess the efficacy of a single intra-articular injection of triamcinolone hexacetonide (THA) in knee osteoarthritis (OA) and examine factors which may relate to treatment efficacy. METHODS--Eighty four patients with clinical and radiographic evidence of knee OA were recruited and randomly allocated to receive either THA (20 mg in 1 ml) or placebo (0.9% normal saline, 1 ml). Follow up assessments evaluated the following outcome variables: patient opinion of overall change in the treated knee, visual analogue pain score (VAS), distance walked in one minute (WD), and Health Assessment Questionnaire modified for lower limb function (HAQ). RESULTS--Seventy eight percent of THA and 49% of placebo treated patients reported overall improvement at week 1 (pread more
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OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines
Weiya Zhang,R W Moskowitz,George Nuki,S Abramson,R D Altman,Nigel K Arden,Sita M A Bierma-Zeinstra,K D Brandt,P Croft,Michael Doherty,Maxime Dougados,Marc C. Hochberg,David J. Hunter,K Kwoh,L S Lohmander,Peter Tugwell +15 more
TL;DR: Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis.
Journal ArticleDOI
EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)
K M Jordan,Nigel K Arden,M Doherty,Bernard Bannwarth,Johannes W. J. Bijlsma,Paul Dieppe,K. P. Günther,H J Hauselmann,Gabriel Herrero-Beaumont,P Kaklamanis,Stefan Lohmander,Burkhard F. Leeb,Michel Lequesne,Bernard Mazières,E. Martin-Mola,Karel Pavelka,Adrian Pendleton,Leonardo Punzi,U Serni,B Swoboda,G. Verbruggen,I Zimmerman-Gorska,Maxime Dougados +22 more
TL;DR: The updated EULAR recommendations support some of the previous propositions published in 2000 but also include modified statements and new propositions.
Reference EntryDOI
Intraarticular corticosteroid for treatment of osteoarthritis of the knee
TL;DR: In this paper, the authors evaluated the efficacy and safety of intra-articular corticosteroids in treatment of Osteoarthritis (OA) of the knee in a single/double blind, placebo-based/comparative study.
Journal ArticleDOI
EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)
A Pendleton,Nigel K Arden,Maxime Dougados,Michael Doherty,B. Bannwarth,J. W. J. Bijlsma,F. Cluzeau,Cyrus Cooper,Paul Dieppe,K-P Gunther,H. J. Hauselmann,G Herrero-Beaumont,P Kaklamanis,B. Leeb,Michel Lequesne,Stefan Lohmander,B Mazieres,E-M Mola,Karel Pavelka,U Serni,B Swoboda,A. A. Verbruggen,G. Weseloh,I. Zimmermann-Gorska +23 more
TL;DR: These are the first clinical guidelines on knee OA to combine an evidence based approach and a consensus approach across a wide range of treatment modalities and it is apparent that certain clinical propositions are supported by substantial research based evidence, while others are not.
Journal ArticleDOI
The placebo effect and its determinants in osteoarthritis – meta-analysis of randomised controlled trials
TL;DR: The placebo effect is effective in the treatment of OA, especially for pain, stiffness and self-reported function, and the size of this effect is influenced by the strength of the active treatment, the baseline disease severity, the route of delivery and the sample size of the study.
References
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The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study.
David T. Felson,David T. Felson,Allan Naimark,Jennifer J. Anderson,Lewis E. Kazis,William P. Castelli,Robert F. Meenan +6 more
TL;DR: It is shown that the prevalence of knee OA increases with age throughout the elderly years, and is almost entirely the result of the marked age-associated increase in the incidence of OA in the women studied.
Journal ArticleDOI
Epidemiology of osteoarthritis: Zoetermeer survey. Comparison of radiological osteoarthritis in a Dutch population with that in 10 other populations.
TL;DR: Differences between men and women were small except for hips and knees; however, severe radiological osteoarthritis was found in a higher proportion in most of the joints in women, and differences between populations were mainly differences in level.
Journal ArticleDOI
Determinants of disability in osteoarthritis of the knee.
TL;DR: Quadriceps strength, knee pain, and age are more important determinants of functional impairment in elderly subjects than the severity of knee osteoarthritis as assessed radiographically.
Journal ArticleDOI
Importance of placement of intra-articular steroid injections.
TL;DR: Strenuous training at low temperatures seems to be pathogenetic for asthma, possibly due to the repeated breathing of large amounts of cold air.
Journal Article
Knee osteoarthritis and physical functioning: evidence from the NHANES I Epidemiologic Followup Study
TL;DR: The association of knee OA with physical functioning was influenced by the radiographic grade of OA and knee pain at NHANES I, suggesting that disease severity and pain are important in anticipating difficulties with physical function in persons with knee Oa.