Journal ArticleDOI
Experiments and simulations of cohesionless particles with varying roughness in a bladed mixer
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In this article, the kinematics of granular flow of cohesionless particles in a bladed mixer were studied experimentally using particle image velocimetry and computationally using the discrete element method.About:
This article is published in Chemical Engineering Science.The article was published on 2010-08-15. It has received 88 citations till now. The article focuses on the topics: Particle & Particle velocity.read more
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The Future of Pharmaceutical Manufacturing Sciences.
Jukka Rantanen,Johannes Khinast +1 more
TL;DR: This review covers important elements of manufacturing sciences, beginning with risk management strategies and design of experiments (DoE) techniques and addressing future manufacturing solutions, covering continuous processing and hot‐melt processing and printing‐based technologies.
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Large-scale CFD–DEM simulations of fluidized granular systems
TL;DR: This work is using the CUDA technology for the particle simulation and introducing a coupling methodology with a commercial CFD-code and CUDA-based DEM-code running on the GPU suitable for large-scale simulations.
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An integrated approach for dynamic flowsheet modeling and sensitivity analysis of a continuous tablet manufacturing process
Fani Boukouvala,Vasilios Niotis,Rohit Ramachandran,Fernando J. Muzzio,Marianthi G. Ierapetritou +4 more
TL;DR: This work aims to identify the challenges in flowsheet model development and simulation for solid-based pharmaceutical processes and show its application and advantages for the integrated simulation and sensitivity analysis of two tablet manufacturing case studies: direct compaction and dry granulation.
Journal ArticleDOI
Polydisperse granular flows in a bladed mixer: Experiments and simulations of cohesionless spheres
TL;DR: In this article, the flow and segregation of polydisperse, spherical particle mixtures in a bladed mixer were investigated using experimental and computational techniques, and numerical simulations showed that the extent of segregation in the bladed mixers can be reduced by introducing intermediate particle sizes in between the smallest and the largest particles.
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Recent progress of continuous crystallization
TL;DR: In this article, the development of continuous crystallization in recent years, including novel crystallizers, control strategies, models and some assistive technologies, is summarized, and the authors conclude that continuous crystallisation is still not as universal as batch crystallization due to the existence of the drawbacks, such as blockage and encrustation.
References
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Journal ArticleDOI
Lagrangian numerical simulation of plug flow of cohesionless particles in a horizontal pipe
TL;DR: In this paper, Lagrangian-type numerical simulation was carried out on plug flow of cohesionless, spherical particles conveyed in a horizontal pipe and the motion of individual particles contacting each other was calculated using the equations of motion and a modified Cundall model.
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Discrete particle simulation of particulate systems: Theoretical developments
TL;DR: This paper reviews the work in this area with special reference to the discrete element method and associated theoretical developments, and covers three important aspects: models for the calculation of the particle–particle and particle–fluid interaction forces, coupling of discrete elements method with computational fluid dynamics to describe particle-fluid flow, and the theories for linking discrete to continuum modelling.
Book
Handbook of Industrial Mixing : Science and Practice
TL;DR: In this paper, the authors present an approach for measuring and quantifying flow properties of Laminar Mixers and their application in the context of flow visualization and flow analysis, including the following: 1.1 Introduction. 2.2 Measurements and distribution functions of flow systems.
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Force Schemes in Simulations of Granular Materials
TL;DR: In this article, the authors systematically study the properties of the force laws most commonly used and compare them with recent experiments on the impact of spheres, and point out possible problems and give criteria for the right choice of parameters.
Journal ArticleDOI
Review and extension of normal force models for the Discrete Element Method
TL;DR: In this paper, a wide range of commonly used force schemes are reviewed based on macroscopic and microscopic accessible parameters like coefficient of restitution, collision time, force, displacement and displacement rate.