Journal ArticleDOI
Extraction chemistry of fermentation product carboxylic acids
A. S. Kertes,C. J. King +1 more
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TLDR
High distribution ratios are measured when long-chain tertiary amines are employed as extractants, forming bulky salts preferentially soluble in the organic phase, and the extractive transfer process obeys the Nernst law.Abstract:
Within the framework of a program aiming to improve the existing extractive recovery technology of fermentation products, the state of the art is critically reviewed. The acids under consideration are propionic, lactic, pyruvic, succinic, fumaric, maleic, malic, itaconic, tartaric, citric, and isocitric, all obtained by the aerobic fermentation of glucose via the glycolytic pathway and glyoxylate bypass. With no exception, it is the undissociated monomeric acid that is extracted into carbon-bonded and phosphorus-bonded oxygen donor extractants. In the organic phase, the acids are usually dimerized. The extractive transfer process obeys the Nernst law, and the measured partition coefficients range from about 0.003 for aliphatic hydrocarbons to about 2 to 3 for aliphatic alcohols and ketones to about 10 or more for organophosphates. Equally high distribution ratios are measured when long-chain tertiary amines are employed as extractants, forming bulky salts preferentially soluble in the organic phase.read more
Citations
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Journal ArticleDOI
Recovery of carboxylic acids produced by fermentation
TL;DR: In-situ removal of carboxylic acid by extraction during fermentation is the most popular approach, but recovery of the extractant can easily lead to waste inorganic salt formation, which counteracts the advantage of the in-Situ removal.
Journal ArticleDOI
Whole-cell biocatalysis in organic media
TL;DR: Correlations between the cellular toxicity or the extractive capacities of different solvents and some of their physical properties have been proposed in order to minimize preliminary, solvent-selection experimental work but also to help in the understanding of the molecular mechanisms of toxicity and extraction.
Journal ArticleDOI
Fermentation of Glucose to Lactic Acid Coupled with Reactive Extraction: A Review
TL;DR: In this article, a suitable extractant−diluent system for lactic acid extraction on the basis of distribution coefficient, toxicity, and feasibility for backextraction is suggested.
Journal ArticleDOI
Comparative assessment of downstream processing options for lactic acid
Book ChapterDOI
Citric acid production.
Marin Berovič,Matic Legisa +1 more
TL;DR: Biochemistry of citric acid fermentation, various microbial strains, as well as various substrates, technological processes and product recovery, World production and economics aspects of this strategically product of bulk biotechnology are discussed.
References
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Journal ArticleDOI
Partition coefficients and their uses
Journal ArticleDOI
The Partition of Organic Compounds Between Higher Alcohols and Water.
Journal ArticleDOI
Solvent equilibriums for extraction of carboxylic acids from water
James M. Wardell,C. Judson King +1 more
Journal ArticleDOI
The acid-binding properties of long-chain aliphatic amines
E. Lester Smith,J. E. Page +1 more
TL;DR: Long-chain aliphatic tertiary amines such as methyldioctylamine and the anion-exchange resin De-acidite C have acid-binding capacities of the same order and can be used as anion exchangers.
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