Journal ArticleDOI
Facile synthesis of 4-substituted 3,4-dihydrocoumarins via an organocatalytic double decarboxylation process.
TLDR
An efficient and convenient double decarboxylation process is documented for the synthesis of 4-substituted 3,4-dihydrocoumarin in moderate to excellent yields under mild reaction conditions (up to 98%).Abstract:
3,4-Dihydrocoumarins, considered to be valuable building blocks, have attracted considerable attention due to their various biological activities. Herein, we have documented an efficient and convenient double decarboxylation process for the synthesis of 4-substituted 3,4-dihydrocoumarin in moderate to excellent yields under mild reaction conditions (up to 98%).read more
Citations
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Journal ArticleDOI
Tandem sp3 C-H functionlization/decarboxylation of 2-alkylazaarenes with coumarin-3-carboxylic acids.
TL;DR: The catalyst-free sp(3) C-H functionalization of 2-alkylazaarenes has been achieved and this method provides facile synthesis of biologically important azaarene-substituted 3,4-dihydro(thio)coumarins in a single step in high yields.
Journal ArticleDOI
Silver-catalyzed decarboxylative cascade radical cyclization of tert-carboxylic acids and o-(allyloxy)arylaldehydes towards chroman-4-one derivatives
Hao Hu,Xiaolan Chen,Xiaolan Chen,Kai Sun,Junchao Wang,Yan Liu,Hui Liu,Bing Yu,Yuanqiang Sun,Lingbo Qu,Yufen Zhao,Yufen Zhao +11 more
TL;DR: In this article, a decarboxylative cascade radical cyclization of tertiary carboxylic acids and o-(allyloxy)arylaldehydes was developed to synthesize 3-alkyl-substituted chroman-4-one derivatives.
Journal ArticleDOI
Transition metal-free decarboxylative alkylation reactions.
TL;DR: This article offers an overview of reaction types and their corresponding mechanisms, highlights some of the advantages and limitations, and focuses on introducing UV and visible light-induced, organocatalyst and peroxide promoted radical processes for decarboxylative alkylation and the formation of C-C bonds.
Journal ArticleDOI
Syntheses and Biological Activities of Chroman-2-ones. A Review
TL;DR: Chroman-2-one (1), also referred to as dihydrocoumarin, and its derivatives have attracted the attention of chemists due to their broad range of properties as discussed by the authors.
Journal ArticleDOI
Organocatalytic Enantioselective Conjugate Addition of Malonic Acid Half Thioesters to Coumarin-3-carboxylic Acids Using N-Heteroarenesulfonyl Cinchona Alkaloid Amides
TL;DR: An efficient enantioselective conjugate addition reaction between coumarin-3-carboxylic acids and malonic acid half thioesters (MAHTs) is disclosed.
References
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Journal ArticleDOI
Target-oriented and diversity-oriented organic synthesis in drug discovery.
TL;DR: Several synthetic planning principles for diversity-oriented synthesis and their role in the drug discovery process are presented in this review.
Journal ArticleDOI
Efficient Activation of Aromatic C-H Bonds for Addition to C-C Multiple Bonds
TL;DR: Efficient electrophilic metalation of aromatic C-H bonds leading to new C-C bond formation through regio- and stereoselective addition to alkynes and alkenes has been realized by a catalytic amount of palladium( II) or platinum(II) compounds in a mixed solvent containing trifluoroacetic acid at room temperature.
Journal ArticleDOI
Recent advances in the stereoselective synthesis of β-amino acids
Mei Liu,Mukund P. Sibi +1 more
Journal ArticleDOI
Efficient functionalization of aromatic C-H bonds catalyzed by gold(III) under mild and solvent-free conditions.
Zhangjie Shi,Chuan He +1 more
TL;DR: A gold(III)-catalyzed carbon-carbon bond formation reaction between arenes and electron-deficient alkynes or alkenes is described and efficient preparation of various coumarins from aryl alkynoates was demonstrated.