Journal ArticleDOI
Falciparum malaria-infected erythrocytes specifically bind to cultured human endothelial cells
Reads0
Chats0
TLDR
The results suggest a specific receptor-ligand interaction between endothelial cells and a component, components, in the knobs of the infected erythrocytes.Abstract:
Erythrocytes infected with the late stages of the human malarial parasite Plasmodium falciparum became attached to a subpopulation of cultured human endothelial cells by knoblike protrusions on the surface of the infected erythrocytes. Infected erythrocytes did not bind to cultured fibroblasts; uninfected erythrocytes did not bind to either endothelial cells or fibroblasts. The results suggest a specific receptor-ligand interaction between endothelial cells and a component, components, in the knobs of the infected erythrocytes.read more
Citations
More filters
Journal ArticleDOI
Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes
Dror I. Baruch,Britten L. Pasloske,Hardeep B. Singh,Xiahui Bi,Xin C. Ma,Michael Feldman,Theodore F. Taraschi,Russell J. Howard +7 more
TL;DR: The cloning of two related PfEMP1 genes from the Malayan Camp parasite strain are described and the molecular basis for antigenic variation in malaria and adherence of infected erythrocytes to host cells can now be pursued.
Journal Article
Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration.
TL;DR: It is concluded that there is no evidence for an inflammatory or immune pathogenesis for human cerebral malaria and that the clinical effects probably relate to anoxia and the metabolic activities of the parasites.
Journal ArticleDOI
Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria.
Georges E. Grau,Luis F. Fajardo,Pierre-François Piguet,Bernard Allet,Paul-Henri Lambert,Pierre Vassalli +5 more
TL;DR: Results indicate that TNF-alpha has an important role in the pathogenesis of cerebral malaria in this murine model and suggest that local accumulation and activation of macrophages may lead to the predominance of lesions in the central nervous system.
Journal ArticleDOI
Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum.
TL;DR: An endothelial-binding line of P. falciparum binds to COS cells transfected with a complementary DNA encoding intercellular adhesion molecule-1, which confirms that CD36 is a cell-adhesion receptor, and finds that this molecule is widely distributed on capillaries and is inducible.
Journal ArticleDOI
Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells.
Britta C. Urban,David J. P. Ferguson,Arnab Pain,Nick Willcox,Magdalena Plebanski,Jonathan M. Austyn,David J. Roberts +6 more
TL;DR: It is shown that intact malaria-infected erythrocytes adhere to dendritic cells, inhibit the maturation of dendedritic cells and subsequently reduce their capacity to stimulate T cells, demonstrating both a novel mechanism by which malaria parasites induce immune dysregulation and a functional role beyond endothelial adhesion for the adhesive phenotypes expressed at the surface of infected ery Throcytes.
References
More filters
Journal ArticleDOI
Human malaria parasites in continuous culture
William Trager,James B. Jensen +1 more
TL;DR: Plasmodium falciparum can now be maintained in continuous culture in human erythrocytes incubated at 38 degrees C in RPMI 1640 medium with human serum under an atmosphere with 7 percent carbon dioxide and low oxygen.
Journal ArticleDOI
Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA
TL;DR: It is demonstrated that it is possible to culture morphologically and immunologically identifiable human endothelial cells for periods up to 5 mo and ABH antigens appropriate to the tissue donor's blood type were not detectable on cultured smooth muscle cells or fibroblasts.
Journal ArticleDOI
Plasmodium falciparum malaria. Ultrastructure of parasitized erythrocytes in cardiac vessels
Sarah A. Luse,Louis H. Miller +1 more
TL;DR: The superficial alterations of the parasitized cells appear to be sites of attachment to venous endothelium and to other parasitized erythrocytes, thus explaining the paucity of circulating cells with maturing parasites in falciparum malaria.
Journal Article
The fine structure of Plasmodium falciparum and its host erythrocytes in natural malarial infections in man.
TL;DR: Electron micrographs of ultra-thin sections of erythrocytes taken from two Liberian children ill with Plasmodium falciparum malaria show that the appliqué forms of this parasite are clearly within the host cell.
Journal ArticleDOI
Distribution of mature trophozoites and schizonts of Plasmodium falciparum in the organs of Aotus trivirgatus, the night monkey.
TL;DR: The sites of schizogony of Plasmodium falciparum in deep vascular tissues were evaluated in two Aotus trivirgatus, night monkeys and a possible relation between deep-vascular schIZogony and the complications of malignant falcIParum malaria was discussed.
Related Papers (5)
Plasmodium falciparum malaria. Ultrastructure of parasitized erythrocytes in cardiac vessels
Sarah A. Luse,Louis H. Miller +1 more