Fecal Feline Coronavirus RNA Shedding and Spike Gene Mutations in Cats with Feline Infectious Peritonitis Treated with GS-441524
Marina L. Meli,Andrea M. Spiri,Katharina Zwicklbauer,D. H. Krentz,Sandra Felten,Michèle Bergmann,Roswitha Dorsch,Kaspar Matiasek,Martin Alberer,Laura Kolberg,Ulrich von Both,H. Hartmann,Regina Hofmann-Lehmann +12 more
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TLDR
Oral treatment with GS-441524 effectively decreased viral RNA loads in feces, blood, and effusion in cats with FIP, indicating that re-shedding can most likely occur if cats are re-exposed to FCoV by their companion cats.Citations
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Detection of Feline Coronavirus Variants in Cats without Feline Infectious Peritonitis
Stéphanie Jähne,Sandra Felten,Michèle Bergmann,Katharina Erber,Kaspar Matiasek,Marina L. Meli,Regina Hofmann-Lehmann,H. Hartmann +7 more
TL;DR: This study aimed to detect feline coronavirus (FCoV) and characterize spike (S) gene mutation profiles in cats suffering from diseases other than feline infectious peritonitis using commercial real-time reverse transcription polymerase chain reaction (RT-qPCR) and reevaluating results by sequencing.
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An updated review of feline coronavirus: mind the two biotypes
Yong Gao,Qian Wang,Xiang-yu Liang,Shuang Zhang,Di Bao,Huan Zhao,Shao-Bai Li,Kai Wang,Guixue Hu,Feng-Shan Gao +9 more
TL;DR: A review of recent progress in FCoV research can be found in this article , where the authors provide a reference for further research on FCoVs and other coronaviruses.
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Clinical Follow-Up and Postmortem Findings in a Cat That Was Cured of Feline Infectious Peritonitis with an Oral Antiviral Drug Containing GS-441524
D. H. Krentz,Katharina Zwicklbauer,Sandra Felten,Michèle Bergmann,Roswitha Dorsch,Regina Hofmann-Lehmann,Marina L. Meli,Andrea M. Spiri,Ulrich von Both,Martin Alberer,Anne Hönl,Kaspar Matiasek,H. Hartmann +12 more
TL;DR: Results prove that oral treatment with GS-441524 leads to the cure of FIP-associated changes and the elimination of FCoV from all tissues.
Journal ArticleDOI
Stopping Feline Coronavirus Shedding Prevented Feline Infectious Peritonitis
Diane Addie,Flora Bellini,Johanna Covell-Ritchie,Ben Crowe,Sheryl Curran,M.W. Fosbery,Stuart Hills,E. Johnson,Carrie Johnson,Steven Lloyd,Oswald Jarrett +10 more
TL;DR: In this paper , the authors found that early treatment of FCoV-infected cats with oral antivirals prevented feline infectious peritonitis (FIP), a potentially lethal pyogranulomatous perivasculitis.
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Patterns of Feline Coronavirus Shedding and Associated Factors in Cats from Breeding Catteries
Sandra Felten,Ute Klein-Richers,Stefan Unterer,Michèle Bergmann,Yury Zablotski,Regina Hofmann-Lehmann,H. Hartmann +6 more
TL;DR: In this article , the authors describe shedding patterns in cats from catteries in which FCoV infection is endemic, and risk factors for high-intensity shedding or non-shedding were analyzed.
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