Journal ArticleDOI
Fetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery.
Charles J. Lockwood,Andrew E. Senyei,Dische Mr,David Casal,K. D. Shah,Swan N. Thung,Lynn Jones,Liane Deligdisch,Thomas J. Garite +8 more
Reads0
Chats0
TLDR
The presence of cervicovaginal fetal fibronectin in the second and third trimesters of pregnancy identifies a subgroup of women who are at high risk for preterm delivery.Abstract:
Background. Preterm delivery is the leading cause of neonatal mortality in the United States, but efforts to address the problem are hampered by the inability to predict accurately which pregnancies are at risk. We postulated that damage to the fetal membranes may release fetal fibronectin into the cervix and vagina, giving rise to a biochemical marker for preterm delivery. Methods. We measured fetal-fibronectin concentrations in cervical and vaginal secretions, amniotic fluid, and maternal plasma with a sensitive immunoassay using the monoclonal antibody FDC-6. Immunohistochemical studies were used to determine the distribution of fetal fibronectin in the placenta and amniochorionic membranes and to ascertain its cell of origin. Results. Women with uncomplicated pregnancies (n = 163) who delivered at term rarely had cervicovaginal fetal-fibronectin concentrations above 0.05 μg per milliliter between 21 and 37 weeks of gestation (11 of 267 cervical samples [4 percent] and 9 of 267 vaginal samples...read more
Citations
More filters
Journal ArticleDOI
Intrauterine infection and preterm delivery.
TL;DR: Preterm delivery is the chief problem in obstetrics today, accounting for 70 percent of perinatal mortality and nearly half of long-term neurologic morbidity, and the remainder follow the spontaneous onset of labor or rupture.
Journal ArticleDOI
The preterm parturition syndrome
Roberto Romero,Jimmy Espinoza,Juan Pedro Kusanovic,Francesca Gotsch,Sonia S. Hassan,Offer Erez,Tinnakorn Chaiworapongsa,Moshe Mazor +7 more
TL;DR: The evidence indicating that the pathological processes implicated in the preterm parturition syndrome include: intrauterine infection/inflammation; uterine ischaemia; (3) uterine overdistension; (4) abnormal allograft reaction; (5) allergy; (6) cervical insufficiency; and (7) hormonal disorders (progesterone related and corticotrophin‐releasing factor related).
Journal ArticleDOI
Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: A randomized placebo-controlled double-blind study
Eduardo Borges da Fonseca,Roberto Eduardo Bittar,Mário Henrique Burlacchini de Carvalho,Marcelo Zugaib +3 more
TL;DR: Prophylactic vaginal progesterone reduced the frequency of uterine contractions and the rate of preterm delivery in women at high risk for prematurity in a high-risk population.
Journal ArticleDOI
Premature Rupture of the Fetal Membranes
Samuel Parry,Jerome F. Strauss +1 more
TL;DR: The membranes surrounding theAmniotic cavity are composed of the amnion and the chorion, which are closely adherent layers consisting of several cell types, including epithelial cells, mesenchymal cells, and trophoblast cells, embedded in a collagenous matrix.
Journal ArticleDOI
Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage
TL;DR: Late miscarriage and pre term delivery are associated with the presence of bacterial vaginosis in early pregnancy, independent of recognised risk factors such as previous preterm delivery.
References
More filters
Journal ArticleDOI
The contribution of low birth weight to infant mortality and childhood morbidity.
TL;DR: Continuation of the current decline in neonatal mortality and reduction of the mortality differentials between high- and low-risk groups require the identification and more effective implementation of strategies for the prevention of low-weight births.
Journal ArticleDOI
The oncofetal domain of fibronectin defined by monoclonal antibody FDC-6: its presence in fibronectins from fetal and tumor tissues and its absence in those from normal adult tissues and plasma
TL;DR: An IgG1 monoclonal antibody, FDC-6, was established, which defines a unique fibronectin (FN) domain, located between the "Hep- 2" and the "Fib-2" domains, in the COOH-terminal region of FNs isolated from hepatoma, sarcoma, and fetal fibroblasts, which indicates the presence of two classes of human FNs.
Journal ArticleDOI
The oncofetal structure of human fibronectin defined by monoclonal antibody FDC-6. Unique structural requirement for the antigenic specificity provided by a glycosylhexapeptide.
H. Matsuura,K. Takio,K. Titani,T. Greene,Steven B. Levery,Mary Ellen K. Salyan,Sen-Itiroh Hakomori +6 more
TL;DR: A single glycosylation at a defined threonine residue of the III CS region may induce conformational changes in the peptide to form the specific oncofetal epitope recognized by FDC-6 antibody, which opens the possibility that a number of other onco Fetal epitopes consist of a peptide and a common O-linked carbohydrate and that the combination produces a conformation specific to cancer or to a stage of development.
Journal ArticleDOI
Can preterm deliveries be prevented
TL;DR: Using a controlled, randomized design, patients determined to be at high risk before 18 weeks' gestation on the basis of the Creasy system are randomly assigned to the Preterm Labor Prevention Clinic or serve as high-risk controls.
Journal Article
Bacterial protease-induced reduction of chorioamniotic membrane strength and elasticity.
James A. McGregor,Janice I. French,David W. Lawellin,Amalia Franco-Buff,Christopher M. Smith,Jim Todd +5 more
TL;DR: In vitro exposure to bacterial collagenase and collagenase-producing microorganisms significantly reduces measures of strength, elasticity, and work to rupture of human amniochorion in a dose-dependent fashion, which supports previous suggestions that infection within the lower uterine segment adjacent to the cervix may mediate some instances of premature rupture of membranes.