Flavonoids and cardiovascular disease
TLDR
Early studies have shown that flavonoids have several anti-inflammatory, antioxidant, antiproliferative, antiplatelet, and provessel function activities, and further studies are necessary for confirmation of the beneficial effects, identification of dose-response relationships, and identification the most bioactive flavonoid.Abstract:
Diets high in flavonoids have long been associated with nutritional recommendations, a healthy lifestyle, and the prevention of chronic diseases. However, identification of specific beneficial effects from specific flavonoids and flavonoid-rich foods has been a challenging area, probably due to a nonessential or conditional role for flavonoids in human nutrition. Nonetheless, recent efforts in the area of high flavonoid–containing foods and cardiovascular disease have begun providing the first demonstrations of specific effects and mechanisms of action in well-controlled studies. The early studies have shown that flavonoids have several anti-atherosclerotic activities including anti-inflammatory, antioxidant, antiproliferative, antiplatelet, and provessel function activities. Cholesterol-lowering and antihypertensive effects of flavonoids have been studied and appear minimal in humans. The studies also demonstrate several possible mechanisms and pleiotropic effects of flavonoids that may be active in redu...read more
Citations
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Variations in phenolic composition and antioxidant properties among 15 basil (Ocimum basilicum L.) cultivars
Eileen M. Kwee,Emily D. Niemeyer +1 more
TL;DR: In this article, the influence of cultivar on the phenolic composition and antioxidant properties of 15 different basil varieties was determined, and a statistically significant effect on total phenolic levels and anthocyanin concentrations was found.
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Effects of Nitrogen Fertilization on the Phenolic Composition and Antioxidant Properties of Basil (Ocimum basilicum L.)
TL;DR: Basil cultivar was determined to have a statistically significant effect on total phenolic levels, rosmarinic and caffeic acid concentrations, and antioxidant activities, and fertilizer effects on polyphenolic compounds and antioxidant activity.
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Catechin degradation with concurrent formation of homo- and heterocatechin dimers during in vitro digestion.
Andrew P. Neilson,Amber S Hopf,Bruce R. Cooper,Michael A. Pereira,Joshua A. Bomser,Mario G. Ferruzzi +5 more
TL;DR: This study provides an expanded profile of catechin dimers of digestive origin that may potentially form following consumption of catechins, and provides a logical basis for initial screening to detect cATEchin digestive products in vivo.
Journal ArticleDOI
The Effects of Flavonoids in Cardiovascular Diseases.
Lorena Ciumărnean,Mircea Vasile Milaciu,Octavia Runcan,Ștefan Cristian Vesa,Andreea Liana Răchișan,Vasile Negrean,Mirela-Georgiana Perné,Valer Donca,T. Alexescu,Ioana Para,Gabriela Dogaru +10 more
TL;DR: This review aims to present the latest data on the classification of flavonoids, their main mechanisms of action in the human body, and the beneficial effects on the physiological and pathological status of the cardiovascular system.
References
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Journal ArticleDOI
Flavonoid intake and risk of chronic diseases
Paul Knekt,Jorma Kumpulainen,Ritva Järvinen,Harri Rissanen,Markku Heliövaara,Antti Reunanen,Timo Hakulinen,Arpo Aromaa +7 more
TL;DR: The risk of some chronic diseases may be lower at higher dietary flavonoid intakes, and a trend toward a reduction in risk of type 2 diabetes was associated with higher quercetin intakes.
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Inflammation as a cardiovascular risk factor.
TL;DR: In randomized, controlled trials, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, in the form of statins, have been shown to provide effective therapy for lowering CRP, in conjunction with their lipid-lowering effects.
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Dietary Isoflavones: Biological Effects and Relevance to Human Health
TL;DR: This review focuses on the more recent studies pertinent to this field and includes, where appropriate, the landmark and historical literature that has led to the exponential increase in interest in phytoestrogens from a clinical nutrition perspective.
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Interactions of Flavonoids with Iron and Copper Ions: A Mechanism for their Antioxidant Activity
Lurdes Mira,M T Fernandez,Marta R. Santos,Rafaella Martins Freitas Rocha,M. H. Florêncio,Keith R. Jennings +5 more
TL;DR: The metal chelating properties of flavonoids suggest that they may play a role in metal-overload diseases and in all oxidative stress conditions involving a transition metal ion.