Journal ArticleDOI
Formation of Local Structures in Protein Folding
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This article is published in Accounts of Chemical Research.The article was published on 1989-01-01. It has received 97 citations till now. The article focuses on the topics: Supersecondary structure & Lattice protein.read more
Citations
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Journal ArticleDOI
Principles of protein folding--a perspective from simple exact models.
Ken A. Dill,Sarina Bromberg,Kaizhi Yue,Klaus M. Fiebig,David P. Yee,Paul Thomas,Hue Sun Chan +6 more
TL;DR: These studies suggest the possibility of creating “foldable” chain molecules other than proteins, and can account for the properties that characterize protein folding: two‐state cooperativity, secondary and tertiary structures, and multistage folding kinetics.
Journal ArticleDOI
Disulfide Bonds and Protein Folding
TL;DR: The mechanism of regenerating the native disulfide bonds suggests an analogous scenario for conformational folding, and engineered covalent cross-links may be used to assay for the association of protein segments in the folding transition state, as illustrated with RNase A.
Journal ArticleDOI
Folding of peptide fragments comprising the complete sequence of proteins. Models for initiation of protein folding. II. Plastocyanin.
TL;DR: In this paper, a series of peptides derived from a simple four-helix bundle protein, myohemerythrin, were synthesized and examined their conformational preferences in aqueous solution using proton nuclear magnetic resonance and circular dichroism spectroscopy.
Journal ArticleDOI
The role of hydrophobic interactions in initiation and propagation of protein folding
TL;DR: Experiments on the folding of mutant apomyoglobins provides corroboration for models based on the hypothesis that folding initiation sites arise from hydrophobic interactions, and provides a putative mechanism for the control of protein-folding initiation and growth by polar/nonpolar sequence propensity alone.
Journal ArticleDOI
Coupled prediction of protein secondary and tertiary structure
Jens Meiler,David Baker +1 more
TL;DR: The architecture of a neural network for secondary structure prediction that utilizes multiple sequence alignments was extended to accept low-resolution nonlocal tertiary structure information as an additional input, which increases the Q3-prediction accuracy by up to 35% and provides insight into the feedback from tertiary to secondary structure.
References
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Journal ArticleDOI
Theory of the Phase Transition between Helix and Random Coil in Polypeptide Chains
Bruno H. Zimm,J. K. Bragg +1 more
TL;DR: In this paper, the transition between the helical and randomly coiled forms of a polypeptide chain is discussed by reference to a simple model that allows bonding only between each group and the third preceding.
Journal ArticleDOI
Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues
TL;DR: Since the present model assumes that only one of the major kinetic phases seen in denaturation reactions is concerned with the denaturation process per se, it is in agreement with numerous thermodynamic studies which show consistency with the two-state model for unfolding.
Journal ArticleDOI
Specific intermediates in the folding reactions of small proteins and the mechanism of protein folding.
Peter S. Kim,Robert L. Baldwin +1 more
Book ChapterDOI
Experimental and theoretical aspects of protein folding.
Anfinsen Cb,Harold A. Scheraga +1 more
TL;DR: The development of conformational energy calculation procedures will enable the three-dimensional structure of a native protein to be predicted from the knowledge of its amino acid sequence and its interactions with the solvent in which it is dissolved.
Related Papers (5)
Specific intermediates in the folding reactions of small proteins and the mechanism of protein folding.
Peter S. Kim,Robert L. Baldwin +1 more