Journal ArticleDOI
Formation of reactive oxygen species in spermatozoa of infertile patients
Akira Iwasaki,Claude Gagnon +1 more
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In this paper, the incidence of reactive oxygen species formation in whole semen and in washed spermatozoa was studied and the effect of the type of sperm washing was also investigated.About:
This article is published in Fertility and Sterility.The article was published on 1992-02-01. It has received 593 citations till now. The article focuses on the topics: Sperm washing & Semen.read more
Citations
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Carotenoids and human health
TL;DR: Carotenoids in general and lycopene in particular are reviewed for their role in human health to support scientific evidence in support of the beneficial role of phytochemicals in the prevention of several chronic diseases.
Journal ArticleDOI
Role of reactive oxygen species in the pathophysiology of human reproduction
TL;DR: High levels of ROS are detrimental to the fertility potential both in natural and assisted conception states.
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Oxidative stress and male infertility—a clinical perspective
TL;DR: This review will provide an overview of oxidative biochemistry related to sperm health and identify which men are most at risk of oxidative infertility, and outline methods available for diagnosing oxidative stress and the various treatments available.
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Role of reactive oxygen species in male infertility.
Rakesh Sharma,Ashok Agarwal +1 more
TL;DR: From the current data it appears that no single adjuvant will be able to enhance the fertilizing capacity of sperm in infertile men, and a combination of the possible strategies that are not toxic at the dosage used would be a feasible approach.
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Journal ArticleDOI
Generation of reactive oxygen species, lipid peroxidation, and human sperm function.
TL;DR: Results are consistent with a causative role for lipid peroxidation in the etiology of defective sperm function and also suggest a possible physiological role for the reactive oxygen species generated by human spermatozoa in mediating sperm-zona interaction.
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Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa.
TL;DR: Studies with scavengers of reactive oxygen species revealed that, while reagents directed against singlet oxygen and the hydroxyl radical were without effect, cytochrome C reduced the response to A23187 by about 50%, suggesting that the superoxide anion radical is a major product of the activated human spermatozoon.
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Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa. Superoxide dismutase as major enzyme protectant against oxygen toxicity.
TL;DR: The results suggest that superoxide dismutase plays the major role in protecting human spermatozoa against lipid peroxidation, and the superoxide Dismutase activity of a fresh sperm sample appears to be a good predictor of the lifetime (up to the complete loss of motility) of that particular sample, and so may prove useful in semen analysis.
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Peroxidative Breakdown of Phospholipids in Human Spermatozoa, Spermicidal Properties of Fatty Acid Peroxides, and Protective Action of Seminal Plasma
TL;DR: The antiperoxidant factor present in human seminal plasma effectively counteracts the toxic effect of exogenous peroxidized fatty acids upon human spermatozoa, but is unable to restore motility lost by lipid peroxide action.
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Significance of Reactive Oxygen Species and Antioxidants in Defining the Efficacy of Sperm Preparation Techniques
R. John Aitken,Jane S. Clarkson +1 more
TL;DR: Assessment of the ability of the antioxidants, butylated hydroxytoluene, and vitamin E, to curtail the peroxidative damage inflicted by cells in response to centrifugation revealed a significant improvement of sperm function in the presence of vitamin E.